FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387643275> ?p ?o ?g. }

• W4387643275 abstract "The appetite-suppressing potential of liver-expressed antimicrobial peptide 2 (LEAP2) and its antagonistic effects on the hunger-inducing hormone ghrelin have attracted scientific interest. It is unclear how LEAP2 is influenced by fasting and how it responds to specific nutrients.The purpose of this investigation was to assess whether LEAP2 concentration (i) decreases after fasting, (ii) increases postprandially, and (iii) is regulated by nutrient sensing in the splanchnic bed.Plasma LEAP2 concentration was measured in blood samples from five clinical crossover trials, following (i) 36 hours of fasting (n=8), (ii) 10 hours of fasting (n=37, baseline data pooled from four of the clinical trials), (iii) Oral and intravenous glucose administration (n=11), (iv) Oral and intravenous Na-lactate administration (n=10), and (v): Oral and intravenous Na-beta-hydroxybutyrate (BHB) administration (n=8). All five trials included healthy males.Compared to a 10-hour fasting period, the median LEAP2 concentration was 38% lower following 36 hours of fasting (p<0.001). Oral administration of glucose elevated, while intravenous glucose administration lowered LEAP2 concentration (intervention x time, p=0.001), resulting in a mean difference of 9 ng/mL (95% CI: 1, 17) after 120 minutes. Oral lactate increased, and intravenous lactate decreased LEAP2 (intervention x time, p=0.007), with a mean difference between interventions of 10 ng/mL (95% CI: 6, 15) after 120 minutes. In contrast, oral and intravenous administration of BHB reduced the LEAP2 concentration (main effect of time, p<0.001).Our investigations show that LEAP2 concentration was lower after a 36-hour fast compared with an overnight fast and that oral delivery of glucose and lactate elevated LEAP2 concentration compared with intravenous administration, whereas LEAP2 concentrations decreased with both oral and intravenous BHB. This indicates that the LEAP2 concentration is sensitive to intestinal exposure to specific substrates, highlighting the need for future studies exploring the relationship between nutrients and LEAP2." @default.
• W4387643275 created "2023-10-15" @default.
• W4387643275 creator A5008672945 @default.
• W4387643275 creator A5022654022 @default.
• W4387643275 creator A5026426127 @default.
• W4387643275 creator A5026896800 @default.
• W4387643275 creator A5028550209 @default.
• W4387643275 creator A5030803630 @default.
• W4387643275 creator A5048834576 @default.
• W4387643275 creator A5051841150 @default.
• W4387643275 creator A5058247633 @default.
• W4387643275 creator A5063420890 @default.
• W4387643275 creator A5064270055 @default.
• W4387643275 date "2023-10-01" @default.
• W4387643275 modified "2023-10-18" @default.
• W4387643275 title "Nutrient sensing: LEAP2 concentration in response to fasting, glucose, lactate, and beta-hydroxybutyrate in healthy young males" @default.
• W4387643275 cites W1980220650 @default.
• W4387643275 cites W2022120264 @default.
• W4387643275 cites W2048194663 @default.
• W4387643275 cites W2112202133 @default.
• W4387643275 cites W2126271200 @default.
• W4387643275 cites W2165768410 @default.
• W4387643275 cites W2400197929 @default.
• W4387643275 cites W2767848831 @default.
• W4387643275 cites W2774279346 @default.
• W4387643275 cites W2883299694 @default.
• W4387643275 cites W2903703296 @default.
• W4387643275 cites W2914784691 @default.
• W4387643275 cites W2968177441 @default.
• W4387643275 cites W2974393119 @default.
• W4387643275 cites W2990809784 @default.
• W4387643275 cites W3045736459 @default.
• W4387643275 cites W3097202681 @default.
• W4387643275 cites W3154945590 @default.
• W4387643275 cites W3194877393 @default.
• W4387643275 cites W4200005728 @default.
• W4387643275 cites W4200336780 @default.
• W4387643275 cites W4205539730 @default.
• W4387643275 cites W4220896095 @default.
• W4387643275 cites W4323037686 @default.
• W4387643275 cites W4365446632 @default.
• W4387643275 cites W4379768673 @default.
• W4387643275 doi "https://doi.org/10.1016/j.ajcnut.2023.10.007" @default.
• W4387643275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37844838" @default.
• W4387643275 hasPublicationYear "2023" @default.
• W4387643275 type Work @default.
• W4387643275 citedByCount "0" @default.
• W4387643275 crossrefType "journal-article" @default.
• W4387643275 hasAuthorship W4387643275A5008672945 @default.
• W4387643275 hasAuthorship W4387643275A5022654022 @default.
• W4387643275 hasAuthorship W4387643275A5026426127 @default.
• W4387643275 hasAuthorship W4387643275A5026896800 @default.
• W4387643275 hasAuthorship W4387643275A5028550209 @default.
• W4387643275 hasAuthorship W4387643275A5030803630 @default.
• W4387643275 hasAuthorship W4387643275A5048834576 @default.
• W4387643275 hasAuthorship W4387643275A5051841150 @default.
• W4387643275 hasAuthorship W4387643275A5058247633 @default.
• W4387643275 hasAuthorship W4387643275A5063420890 @default.
• W4387643275 hasAuthorship W4387643275A5064270055 @default.
• W4387643275 hasBestOaLocation W43876432751 @default.
• W4387643275 hasConcept C126322002 @default.
• W4387643275 hasConcept C134018914 @default.
• W4387643275 hasConcept C142724271 @default.
• W4387643275 hasConcept C204787440 @default.
• W4387643275 hasConcept C27081682 @default.
• W4387643275 hasConcept C2777056448 @default.
• W4387643275 hasConcept C71924100 @default.
• W4387643275 hasConcept C87813604 @default.
• W4387643275 hasConceptScore W4387643275C126322002 @default.
• W4387643275 hasConceptScore W4387643275C134018914 @default.
• W4387643275 hasConceptScore W4387643275C142724271 @default.
• W4387643275 hasConceptScore W4387643275C204787440 @default.
• W4387643275 hasConceptScore W4387643275C27081682 @default.
• W4387643275 hasConceptScore W4387643275C2777056448 @default.
• W4387643275 hasConceptScore W4387643275C71924100 @default.
• W4387643275 hasConceptScore W4387643275C87813604 @default.
• W4387643275 hasLocation W43876432751 @default.
• W4387643275 hasLocation W43876432752 @default.
• W4387643275 hasOpenAccess W4387643275 @default.
• W4387643275 hasPrimaryLocation W43876432751 @default.
• W4387643275 hasRelatedWork W1966504330 @default.
• W4387643275 hasRelatedWork W1966775726 @default.
• W4387643275 hasRelatedWork W1979139803 @default.
• W4387643275 hasRelatedWork W1991560548 @default.
• W4387643275 hasRelatedWork W2030889776 @default.
• W4387643275 hasRelatedWork W2037631372 @default.
• W4387643275 hasRelatedWork W2040058909 @default.
• W4387643275 hasRelatedWork W2132898409 @default.
• W4387643275 hasRelatedWork W2748952813 @default.
• W4387643275 hasRelatedWork W4249176446 @default.
• W4387643275 isParatext "false" @default.
• W4387643275 isRetracted "false" @default.
• W4387643275 workType "article" @default.