FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387643645> ?p ?o ?g. }

• W4387643645 endingPage "117312" @default.
• W4387643645 startingPage "117312" @default.
• W4387643645 abstract "Prinsepia utilis (PU) Royle, native to the Himalayan region, is a deciduous thorny shrub with numerous traditional uses of its roots, leaves and seeds for treatment of conditions such as rheumatic pain, joint pain, arthritis, and inflammation.Keeping in mind the growing demand of products of natural origin as alternate medicine, the present study was undertaken to scientifically validate for the first time the traditional claims of healing pain and inflammation by evaluating the fatty oil isolated from the seeds using established in vitro and in vivo models.PU Seeds were Soxhlet extracted using n-hexane and fatty oil was isolated. Chemical composition of the oil was established with the aid of Gas Chromatography-Flame Ionization Detection (GC-FID) and Gas Chromatography-Mass Spectrometry (GC-MS). The oil was then subjected to in vitro anti-inflammatory activity by following the established protocols of trypsin inhibitory and bovine serum albumin denaturation assays. The acute toxicity of the oil was also studied using OECD guidelines 423. The anti-inflammatory property of the oil was further evaluated using carrageenan-induced and formalin-induced edema in the rat paw. Moreover, hot plate latency and tail immersion assay were employed to evaluate analgesic activity of the oil. To establish the quality of the oil, various physicochemical properties were also studied.GC-FID and GC-MS analysis of the oil revealed the presence of linoleic acid (59.06 ± 0.00%), oleic acid (28.11 ± 0.01%), palmitic acid (9.51 ± 0.01%) and stearic acid (3.32 ± 0.01%). In vitro trypsin inhibitory and bovine serum albumin denaturation assay revealed dose-dependent notable activity of the oil with IC50 value of 63.57 μg/mL and 518.14 μg/mL, respectively. The physico-chemical characterization demonstrated that the oil possesses a low acidity and a high oxidative stability index. The oil was found to be non-toxic and displayed effective anti-inflammatory activities with significant inhibition till 4 h in carrageenan-induced and formalin-induced rat paw edema at maximum tested dose of 200 mg/kg b.w. The oil also exhibited significant results in hot plate latency and tail immersion assay with positive effects showing up to 4 h after dose administration.These findings, besides supporting the traditional claims, suggest that P. utilis seed oil has potential therapeutic applications as a natural anti-inflammatory and analgesic agent. Further studies are warranted to explore its mechanisms of action and potential use in pharmaceutical and nutraceutical industries." @default.
• W4387643645 created "2023-10-15" @default.
• W4387643645 creator A5008553074 @default.
• W4387643645 creator A5064502235 @default.
• W4387643645 creator A5065903999 @default.
• W4387643645 creator A5087875279 @default.
• W4387643645 date "2023-10-01" @default.
• W4387643645 modified "2023-10-18" @default.
• W4387643645 title "Exploring the therapeutic potential of Prinsepia utilis Royle seed oil: A comprehensive study on chemical composition, physicochemical properties, anti-inflammatory, and analgesic activities" @default.
• W4387643645 cites W1523117766 @default.
• W4387643645 cites W1661883991 @default.
• W4387643645 cites W1969725849 @default.
• W4387643645 cites W1981819970 @default.
• W4387643645 cites W1982816733 @default.
• W4387643645 cites W1985378603 @default.
• W4387643645 cites W1995600688 @default.
• W4387643645 cites W2007900773 @default.
• W4387643645 cites W2009345240 @default.
• W4387643645 cites W2011094325 @default.
• W4387643645 cites W2011480883 @default.
• W4387643645 cites W2012991711 @default.
• W4387643645 cites W2022292830 @default.
• W4387643645 cites W2028862173 @default.
• W4387643645 cites W2031596649 @default.
• W4387643645 cites W2036267752 @default.
• W4387643645 cites W2036779377 @default.
• W4387643645 cites W2037455161 @default.
• W4387643645 cites W2087541419 @default.
• W4387643645 cites W2089858198 @default.
• W4387643645 cites W2144926438 @default.
• W4387643645 cites W2151119400 @default.
• W4387643645 cites W2734007740 @default.
• W4387643645 cites W2761552595 @default.
• W4387643645 cites W2902134732 @default.
• W4387643645 cites W2964783773 @default.
• W4387643645 cites W3106692639 @default.
• W4387643645 cites W3158120609 @default.
• W4387643645 cites W3164421364 @default.
• W4387643645 cites W3173998133 @default.
• W4387643645 cites W4220660755 @default.
• W4387643645 cites W4221037775 @default.
• W4387643645 cites W4360991720 @default.
• W4387643645 cites W4366588337 @default.
• W4387643645 doi "https://doi.org/10.1016/j.jep.2023.117312" @default.
• W4387643645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37844743" @default.
• W4387643645 hasPublicationYear "2023" @default.
• W4387643645 type Work @default.
• W4387643645 citedByCount "0" @default.
• W4387643645 crossrefType "journal-article" @default.
• W4387643645 hasAuthorship W4387643645A5008553074 @default.
• W4387643645 hasAuthorship W4387643645A5064502235 @default.
• W4387643645 hasAuthorship W4387643645A5065903999 @default.
• W4387643645 hasAuthorship W4387643645A5087875279 @default.
• W4387643645 hasConcept C185592680 @default.
• W4387643645 hasConcept C2779703632 @default.
• W4387643645 hasConcept C2779936771 @default.
• W4387643645 hasConcept C2780809830 @default.
• W4387643645 hasConcept C2780820201 @default.
• W4387643645 hasConcept C2781003072 @default.
• W4387643645 hasConcept C2781403372 @default.
• W4387643645 hasConcept C31903555 @default.
• W4387643645 hasConcept C43617362 @default.
• W4387643645 hasConcept C543025807 @default.
• W4387643645 hasConcept C55493867 @default.
• W4387643645 hasConcept C556039675 @default.
• W4387643645 hasConcept C71924100 @default.
• W4387643645 hasConcept C98274493 @default.
• W4387643645 hasConceptScore W4387643645C185592680 @default.
• W4387643645 hasConceptScore W4387643645C2779703632 @default.
• W4387643645 hasConceptScore W4387643645C2779936771 @default.
• W4387643645 hasConceptScore W4387643645C2780809830 @default.
• W4387643645 hasConceptScore W4387643645C2780820201 @default.
• W4387643645 hasConceptScore W4387643645C2781003072 @default.
• W4387643645 hasConceptScore W4387643645C2781403372 @default.
• W4387643645 hasConceptScore W4387643645C31903555 @default.
• W4387643645 hasConceptScore W4387643645C43617362 @default.
• W4387643645 hasConceptScore W4387643645C543025807 @default.
• W4387643645 hasConceptScore W4387643645C55493867 @default.
• W4387643645 hasConceptScore W4387643645C556039675 @default.
• W4387643645 hasConceptScore W4387643645C71924100 @default.
• W4387643645 hasConceptScore W4387643645C98274493 @default.
• W4387643645 hasLocation W43876436451 @default.
• W4387643645 hasLocation W43876436452 @default.
• W4387643645 hasOpenAccess W4387643645 @default.
• W4387643645 hasPrimaryLocation W43876436451 @default.
• W4387643645 hasRelatedWork W1965123752 @default.
• W4387643645 hasRelatedWork W2068475321 @default.
• W4387643645 hasRelatedWork W2090894718 @default.
• W4387643645 hasRelatedWork W2348103409 @default.
• W4387643645 hasRelatedWork W2350109037 @default.
• W4387643645 hasRelatedWork W2380757310 @default.
• W4387643645 hasRelatedWork W2387857318 @default.
• W4387643645 hasRelatedWork W2544873335 @default.
• W4387643645 hasRelatedWork W2797779095 @default.
• W4387643645 hasRelatedWork W3014225798 @default.
• W4387643645 isParatext "false" @default.
• W4387643645 isRetracted "false" @default.
• W4387643645 workType "article" @default.