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• W4387643695 abstract "In various cultures around the world, Mentha longifolia (L.) (Lamiaceae) has a range of traditional therapeutic applications and varied pharmacological properties, including gastrointestinal illnesses, respiratory disorders, infectious diseases, inflammatory diseases, and menstrual problems. This plant is considered in folk medicine for its antibacterial properties. In this study, we explored the phytochemical profile and the pre-clinical safety of M. longifolia aqueous extract aerial part by acute and subacute toxicity in male and female Swiss albino mice. High-performance Liquid Chromatography Diode Array Detector (HPLC-DAD) was used to provide qualitative and quantitative analyses of phenolic compounds of M. longifolia aqueous extract. In acute toxicity experiments, four distinct groups of mice (n = 5/group/sex) were administered Mentha longifolia aqueous extract at single oral dosages of 0.5; 1; 2; 4, and 8 g/kg BW given by gavage and intraperitoneal for up to 14 days. Regarding the subacute toxicity investigation, Swiss albino mice were given M. longifolia aqueous extract orally at dosages of 100; 500; and 1000 mg/kg BW daily for 28 days. Body weight is measured every 7 days and suggested biochemical and hematological parameters were quantified, and at the finish of 28 days of daily administration, sections of the liver, kidney, and spleen were histologically evaluated for showing damage to organs. The data of High-performance Liquid chromatography analysis revealed that M. longifolia aqueous extract was rich in interesting phytochemical compounds, mainly quercetin, and rutin, followed by a hydroxybenzoic acid-like syringic acid. Regarding the acute test in mice, no mortality or symptoms of toxicity were detected following oral administration with a single dose of M. longifolia aqueous extract at any dosage limit up to 4 g/kg, which was the no-observed side effect threshold (NOAEL). The mortality rate as well as acute toxicity of the M. longifolia aqueous extract delivered intraperitoneally, are increased progressively with increasing dosage. The non-observed adverse effect level (NOAEL) for the intraperitoneal dosage was 1 g/kg BW, and the lowest observed adverse effect level (LOAEL) was 2 g/kg BW, the estimated acute toxicity (LD50) of intraperitoneally given M. longifolia aqueous extract in mice was 4.800 g/kg BW. Concerning subacute examinations in mice, the M. longifolia aqueous extract did not induce substantial modifications in biochemical or hematological indicators, preserve for a slight increase in creatinine and urea levels. At the end of the experiment, a histopathological examination of the kidneys, liver, and spleen revealed normal architecture, suggesting no morphological damage. The data we obtained indicate that acute or subacute administration of Mentha longifolia aqueous extract is relatively non-toxic in male and female Swiss albino mice, showing the safety of humans." @default.
• W4387643695 created "2023-10-15" @default.
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• W4387643695 date "2023-10-01" @default.
• W4387643695 modified "2023-10-17" @default.
• W4387643695 title "Phenolic profile, acute and subacute toxicity of an aqueous extract from Moroccan Mentha longifolia L. aerial part in Swiss Albino mice model" @default.
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• W4387643695 doi "https://doi.org/10.1016/j.jep.2023.117293" @default.
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