Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387647310> ?p ?o ?g. }
- W4387647310 endingPage "115656" @default.
- W4387647310 startingPage "115656" @default.
- W4387647310 abstract "Alzheimer's disease (AD), a neurodegenerative condition, is defined by neurofibrillary tangles, amyloid plaques, and gradual cognitive decline. Regardless of the advances in understanding AD's pathogenesis and progression, its causes are still contested, and there are currently no efficient therapies for the illness. The post-mortem analyses revealed widespread neuronal loss in multiple brain regions in AD, evidenced by a decrease in neuronal density and correlated with the disease's progression and cognitive deterioration. AD's neurodegeneration is complicated, and different types of neuronal cell death, alone or in combination, play crucial roles in this process. Recently, the involvement of non-apoptotic programmed cell death in the neurodegenerative mechanisms of AD has received a lot of attention. Aberrant activation of necroptosis and ferroptosis, two newly discovered forms of regulated non-apoptotic cell death, is thought to contribute to neuronal cell death in AD. In this review, we first address the main features of necroptosis and ferroptosis, cellular signaling cascades, and the mechanisms involved in AD pathology. Then, we discuss the latest therapies targeting necroptosis and ferroptosis in AD animal/cell models and human research to provide vital information for AD treatment." @default.
- W4387647310 created "2023-10-15" @default.
- W4387647310 creator A5029889770 @default.
- W4387647310 creator A5037882634 @default.
- W4387647310 creator A5042325286 @default.
- W4387647310 creator A5065235874 @default.
- W4387647310 creator A5091298501 @default.
- W4387647310 date "2023-12-01" @default.
- W4387647310 modified "2023-10-18" @default.
- W4387647310 title "Molecular mechanism and potential therapeutic targets of necroptosis and ferroptosis in Alzheimer's disease" @default.
- W4387647310 cites W1141771209 @default.
- W4387647310 cites W1560616917 @default.
- W4387647310 cites W1569630943 @default.
- W4387647310 cites W1589269270 @default.
- W4387647310 cites W1594144439 @default.
- W4387647310 cites W174314568 @default.
- W4387647310 cites W190731049 @default.
- W4387647310 cites W1955466454 @default.
- W4387647310 cites W1963882244 @default.
- W4387647310 cites W1963945544 @default.
- W4387647310 cites W1964271667 @default.
- W4387647310 cites W1965389900 @default.
- W4387647310 cites W1967013632 @default.
- W4387647310 cites W1968424168 @default.
- W4387647310 cites W1969061171 @default.
- W4387647310 cites W1973932627 @default.
- W4387647310 cites W1978252394 @default.
- W4387647310 cites W1979871416 @default.
- W4387647310 cites W1980645669 @default.
- W4387647310 cites W1983760936 @default.
- W4387647310 cites W1989420290 @default.
- W4387647310 cites W1994018301 @default.
- W4387647310 cites W1997128330 @default.
- W4387647310 cites W1997183854 @default.
- W4387647310 cites W2001289073 @default.
- W4387647310 cites W2001591118 @default.
- W4387647310 cites W2002239634 @default.
- W4387647310 cites W2002490399 @default.
- W4387647310 cites W2003945664 @default.
- W4387647310 cites W2012178932 @default.
- W4387647310 cites W2017026767 @default.
- W4387647310 cites W2019506702 @default.
- W4387647310 cites W2020427805 @default.
- W4387647310 cites W2022363001 @default.
- W4387647310 cites W2026844934 @default.
- W4387647310 cites W2030249003 @default.
- W4387647310 cites W2039314393 @default.
- W4387647310 cites W2042330636 @default.
- W4387647310 cites W2042400232 @default.
- W4387647310 cites W2049132241 @default.
- W4387647310 cites W2050769195 @default.
- W4387647310 cites W2053364373 @default.
- W4387647310 cites W2054113864 @default.
- W4387647310 cites W2057880516 @default.
- W4387647310 cites W2059081843 @default.
- W4387647310 cites W2067107606 @default.
- W4387647310 cites W2068318042 @default.
- W4387647310 cites W2068972343 @default.
- W4387647310 cites W2087560082 @default.
- W4387647310 cites W2101553919 @default.
- W4387647310 cites W2102364770 @default.
- W4387647310 cites W2106443532 @default.
- W4387647310 cites W2110464595 @default.
- W4387647310 cites W2110796758 @default.
- W4387647310 cites W2112867510 @default.
- W4387647310 cites W2113651744 @default.
- W4387647310 cites W2120095464 @default.
- W4387647310 cites W2132164244 @default.
- W4387647310 cites W2136040587 @default.
- W4387647310 cites W2151292085 @default.
- W4387647310 cites W2152121157 @default.
- W4387647310 cites W2154452751 @default.
- W4387647310 cites W2154748402 @default.
- W4387647310 cites W2155162140 @default.
- W4387647310 cites W2155589424 @default.
- W4387647310 cites W2158115535 @default.
- W4387647310 cites W2163294546 @default.
- W4387647310 cites W2166704587 @default.
- W4387647310 cites W2167063200 @default.
- W4387647310 cites W2174098335 @default.
- W4387647310 cites W2214404521 @default.
- W4387647310 cites W2265728551 @default.
- W4387647310 cites W2282246233 @default.
- W4387647310 cites W2283739034 @default.
- W4387647310 cites W2289784817 @default.
- W4387647310 cites W2320148097 @default.
- W4387647310 cites W2336745021 @default.
- W4387647310 cites W2408942357 @default.
- W4387647310 cites W2414659015 @default.
- W4387647310 cites W2470889344 @default.
- W4387647310 cites W2510053021 @default.
- W4387647310 cites W2519786994 @default.
- W4387647310 cites W2520340275 @default.
- W4387647310 cites W2550324626 @default.
- W4387647310 cites W2552728987 @default.
- W4387647310 cites W2558678546 @default.
- W4387647310 cites W2583594489 @default.
- W4387647310 cites W2583631769 @default.