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- W4387648749 abstract "NMR screening methods based on 19F spin-spin relaxation time (19F-T2) were applied to fluorinated compounds bound to human serum albumin. Diflunisal and fleroxacin (the fluorinated compounds) contain two and three fluorine atoms per molecule, respectively, and are suitable as the model system for 19F NMR analysis. It was shown that 19F-T2 was more sensitive in monitoring the binding affinity to the target protein than 19F spin-lattice relaxation time (19F-T1). The comparisons of 19F signal intensities acquired at different echo times using 19F-T2 pulse sequence were also shown to be an effective means of assessing complex formation for fluorinated compounds." @default.
- W4387648749 created "2023-10-15" @default.
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- W4387648749 date "2023-10-15" @default.
- W4387648749 modified "2023-10-16" @default.
- W4387648749 title "NMR screening method based on 19F spin–spin relaxation time for analyses of fluorinated compound bound to proteins" @default.
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- W4387648749 doi "https://doi.org/10.1007/s44211-023-00435-0" @default.
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