Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387650398> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W4387650398 abstract "The liver is not only a digestive gland, but also an immune tissue that receives a double infusion from the hepatic artery and the hepatic portal vein. Receiving 80% of its blood supply from the intestine through the hepatic portal vein system, the liver is enriched with a large number of innate immune cells, which carry out the process of immune response by detecting pathogens entering the organism through the intestine. The intestine and liver communicate extensively through the bile ducts, portal vein and the somatic circulation, a bidirectional communication known as the intestinal-liver axis. The mammalian gut is considered an important microbial ecosystem. The interplay between the natural immune system and microbes coordinates the physiology of the whole organism, and in specific mammalian lineages, there is a dependency between the host and its associated microbes. To this end, we explored the regulatory mechanisms of natural immunity genes at the genome-wide level. Based on comparative genomics, 1473 bovine natural immunity genes were obtained by collecting the latest reports of human natural immunity genes and updated bovine genomic data for comparison, and a bovine natural immunity gene database was initially constructed to screen and match calf liver natural immunity differential genes mainly affected by the phylum Mimosoidea and the phylum Thick-walled Bacteria, and 16 differentially expressed natural immunity genes were obtained. In addition, the results of IPA analysis indicated that the upstream factor IL-2 initiated the PI3K/AKt/mTOR, mitogen-activated protein kinase (MAPK) pathway and JAK/STAT5 pathway, leading to the liver's involvement in gut microbial immune regulation." @default.
- W4387650398 created "2023-10-16" @default.
- W4387650398 creator A5006199449 @default.
- W4387650398 creator A5007088437 @default.
- W4387650398 creator A5033744329 @default.
- W4387650398 creator A5046786967 @default.
- W4387650398 creator A5055229622 @default.
- W4387650398 creator A5077353181 @default.
- W4387650398 creator A5087445032 @default.
- W4387650398 date "2023-10-12" @default.
- W4387650398 modified "2023-10-16" @default.
- W4387650398 title "IL-2 Acclimatizes Newborn Calves to Beneficial Microorganisms via Intestine-Liver Axis" @default.
- W4387650398 doi "https://doi.org/10.20944/preprints202310.0733.v1" @default.
- W4387650398 hasPublicationYear "2023" @default.
- W4387650398 type Work @default.
- W4387650398 citedByCount "0" @default.
- W4387650398 crossrefType "posted-content" @default.
- W4387650398 hasAuthorship W4387650398A5006199449 @default.
- W4387650398 hasAuthorship W4387650398A5007088437 @default.
- W4387650398 hasAuthorship W4387650398A5033744329 @default.
- W4387650398 hasAuthorship W4387650398A5046786967 @default.
- W4387650398 hasAuthorship W4387650398A5055229622 @default.
- W4387650398 hasAuthorship W4387650398A5077353181 @default.
- W4387650398 hasAuthorship W4387650398A5087445032 @default.
- W4387650398 hasBestOaLocation W43876503981 @default.
- W4387650398 hasConcept C104317684 @default.
- W4387650398 hasConcept C136449434 @default.
- W4387650398 hasConcept C203014093 @default.
- W4387650398 hasConcept C2779341262 @default.
- W4387650398 hasConcept C54355233 @default.
- W4387650398 hasConcept C86803240 @default.
- W4387650398 hasConcept C8891405 @default.
- W4387650398 hasConceptScore W4387650398C104317684 @default.
- W4387650398 hasConceptScore W4387650398C136449434 @default.
- W4387650398 hasConceptScore W4387650398C203014093 @default.
- W4387650398 hasConceptScore W4387650398C2779341262 @default.
- W4387650398 hasConceptScore W4387650398C54355233 @default.
- W4387650398 hasConceptScore W4387650398C86803240 @default.
- W4387650398 hasConceptScore W4387650398C8891405 @default.
- W4387650398 hasLocation W43876503981 @default.
- W4387650398 hasOpenAccess W4387650398 @default.
- W4387650398 hasPrimaryLocation W43876503981 @default.
- W4387650398 hasRelatedWork W1495541589 @default.
- W4387650398 hasRelatedWork W1987802636 @default.
- W4387650398 hasRelatedWork W2066136773 @default.
- W4387650398 hasRelatedWork W2087547757 @default.
- W4387650398 hasRelatedWork W2158827209 @default.
- W4387650398 hasRelatedWork W2190283986 @default.
- W4387650398 hasRelatedWork W2316042956 @default.
- W4387650398 hasRelatedWork W2565121077 @default.
- W4387650398 hasRelatedWork W2570867257 @default.
- W4387650398 hasRelatedWork W581377774 @default.
- W4387650398 isParatext "false" @default.
- W4387650398 isRetracted "false" @default.
- W4387650398 workType "article" @default.