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- W4387650564 abstract "Glioblastoma (GBM) is one of the most aggressive and intricate forms of brain cancer, demanding novel therapeutic interventions. The role of transcription factors in epigenetic regulation has emerged as a promising avenue for targeting GBM. This comprehensive review seeks to explore the complex interplay between specific transcription factors such as SNAI2, FOXA1, YAP1, TWIST1, ZEB1, and NF-kB, and their role in GBM progression and therapy. The focus extends to innovative therapeutic strategies, including epigenetic modifiers, targeted therapies, and CRISPR/Cas9 technology. A unique aspect of this review highlights the connection between transcription factors, neoantigen presentation, and personalized immunotherapy in GBM. By delving into current research, clinical trials, and immunological data, this review emphasizes the significant potential of targeting transcription factors for personalized immunotherapy in GBM. The challenges, future perspectives, and ethical considerations are also critically discussed, offering a complete and thought-provoking insight into a vital and rapidly evolving field." @default.
- W4387650564 created "2023-10-16" @default.
- W4387650564 creator A5037439647 @default.
- W4387650564 creator A5067184182 @default.
- W4387650564 date "2023-10-10" @default.
- W4387650564 modified "2023-10-16" @default.
- W4387650564 title "From Transcription Factors to Personalized Vaccines: A Multifaceted Review of Glioblastoma Research and Treatment" @default.
- W4387650564 doi "https://doi.org/10.20944/preprints202310.0607.v1" @default.
- W4387650564 hasPublicationYear "2023" @default.
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