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- W4387650642 abstract "Intense alterations of mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and represent an important cause of morbidity and decreased quality of life. These disor-ders have traditionally been defined as renal osteodystrophy and classified based on bone biop-sy, but due to a lack of bone biopsy data and validated radiological methods to evaluate bone morphology in children, it has been difficult to adequately evaluate renal osteodystrophy in pe-diatric CKD. This has led to suboptimal management of bone disorders in children. CKD-mineral and bone disorder (CKD-MBD) is a new term used to describe a systemic disorder of mineral and bone metabolism as a result of CKD. CKD-MBD is a triad of biochemical imbalances of cal-cium, phosphate, parathyroid hormone and vitamin D, bone abnormalities and soft tissue calci-fication. This literature review aims to explore the pathogenesis, diagnostic approach, and treat-ment of CKD-MBD in children and the specific consequences of renal osteodystrophy on growing skeleton, with a specific focus on the biological basis of this peculiar condition." @default.
- W4387650642 created "2023-10-16" @default.
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- W4387650642 date "2023-10-14" @default.
- W4387650642 modified "2023-10-16" @default.
- W4387650642 title "Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review" @default.
- W4387650642 doi "https://doi.org/10.20944/preprints202309.2108.v1" @default.
- W4387650642 hasPublicationYear "2023" @default.
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