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• W4387652191 abstract "STING activation by cyclic dinucleotides in mammals induces interferon- and NFkB -related gene expression, and the lipidation of LC3B at Golgi membranes. While mechanisms of the interferon response are well understood, the mechanisms of NFkB activation mediated by STING remain unclear. We report that STING activation induces K63- and M1-linked/linear ubiquitin chain formation at LC3B-associated Golgi membranes. Loss of the LUBAC E3 ubiquitin ligase prevents formation of linear, but not K63-linked ubiquitin chains or STING activation and inhibits STING-induced NFkB and IRF3-mediated signaling in monocytic THP1 cells. The proton channel activity of STING is also important for both K63 and linear ubiquitin chain formation, and NFkB- and interferon-related gene expression. Thus, LUBAC synthesis of linear ubiquitin chains regulates STING-mediated innate immune signaling." @default.
• W4387652191 created "2023-10-16" @default.
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• W4387652191 date "2023-10-15" @default.
• W4387652191 modified "2023-10-18" @default.
• W4387652191 title "STING induces LUBAC-mediated synthesis of linear ubiquitin chains to stimulate innate immune signaling" @default.
• W4387652191 doi "https://doi.org/10.1101/2023.10.14.562349" @default.
• W4387652191 hasPublicationYear "2023" @default.
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