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- W4387652197 abstract "Copper plays an antioxidant role in biological reactions. This study examined the impact of copper-methionine supplementation on the matrix metalloproteinase-2 (MMP-2) activity and gene expression in the liver and brain of broiler chickens subjected to cold temperature. A total of 480 broiler chickens were assigned to 6 groups and reared under either low (15-19 C) or normal temperature (25-28 C) and fed a basal diet enriched with different concentrations of copper-methionine (Cu-Met) supplementation (0, 100 or 200 mg.kg-1). Ascites was exclusively observed in broiler chickens kept in low temperature and fed with basal diet without Cu-Met during the seventh week, identified by the presence of abdominal fluid accumulation. Broilers' livers and brains were separated for MMP-2 and tissue inhibitor of metalloproteinase-2 (TIMP-2) analysis. Results of gelatin zymography on these samples demonstrated that incidence of ascites was associated with increased MMP-2 levels in liver and brain. MMP-2 activity assay confirmed the results obtained by zymography. RT-qPCR experiments revealed an upregulation in the mRNA expression of MMP-2. In contrast, the treatments did not induce significant alterations in TIMP-2 levels. Results suggest that oral copper-methionine can decrease the ascites occurrence and might be useful for prevention of ascites in broiler chickens. Key words: Matrix metalloproteinase-2 (MMP-2); Tissue inhibitor of metalloproteinase-2 (TIMP-2); Copper-methionine; Liver; Brain; Broiler chicken; Ascites; Cold stress" @default.
- W4387652197 created "2023-10-16" @default.
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- W4387652197 date "2023-10-15" @default.
- W4387652197 modified "2023-10-17" @default.
- W4387652197 title "Oral copper-methionine decreases matrix metalloproteinase-2 activity in the liver and brain of broiler chickens subjected to cold stress for ascites incidence" @default.
- W4387652197 doi "https://doi.org/10.1101/2023.10.14.562342" @default.
- W4387652197 hasPublicationYear "2023" @default.
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