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- W4387653425 endingPage "1543" @default.
- W4387653425 startingPage "1543" @default.
- W4387653425 abstract "Amphotericin B is the oldest antifungal molecule which is still currently widely used in clinical practice, in particular for the treatment of invasive diseases, even though it is not devoid of side effects (particularly nephrotoxicity). Recently, its redox properties (i.e., both prooxidant and antioxidant) have been highlighted in the literature as mechanisms involved in both its activity and its toxicity. Interestingly, similar properties can be described for inorganic nanoparticles. In the first part of the present review, the redox properties of Amphotericin B and inorganic nanoparticles are discussed. Then, in the second part, inorganic nanoparticles as carriers of the drug are described. A special emphasis is given to their combined redox properties acting either as a prooxidant or as an antioxidant and their connection to the activity against pathogens (i.e., fungi, parasites, and yeasts) and to their toxicity. In a majority of the published studies, inorganic nanoparticles carrying Amphotericin B are described as having a synergistic activity directly related to the rupture of the redox homeostasis of the pathogen. Due to the unique properties of inorganic nanoparticles (e.g., magnetism, intrinsic anti-infectious properties, stimuli-triggered responses, etc.), these nanomaterials may represent a new generation of medicine that can synergistically enhance the antimicrobial properties of Amphotericin B." @default.
- W4387653425 created "2023-10-16" @default.
- W4387653425 creator A5033618246 @default.
- W4387653425 creator A5059799398 @default.
- W4387653425 creator A5072953717 @default.
- W4387653425 creator A5074688010 @default.
- W4387653425 date "2023-10-15" @default.
- W4387653425 modified "2023-10-16" @default.
- W4387653425 title "Inorganic Nanoparticles: Tools to Emphasize the Janus Face of Amphotericin B" @default.
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