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- W4387653460 abstract "Bacteriophage therapy is considered one of the most promising tools to control zoonotic bacteria, such as Salmonella, in broiler production. Phages exhibit high specificity for their targeted bacterial hosts, causing minimal disruption to the niche microbiota. However, data on the gut environment’s response to phage therapy in poultry are limited. This study investigated the influence of Salmonella phage on host physiology through caecal microbiota and metabolome modulation using high-throughput 16S rRNA gene sequencing and an untargeted metabolomics approach. We employed 24 caecum content samples and 24 blood serum samples from 4-, 5- and 6-week-old broilers from a previous study where Salmonella phages were administered via feed in Salmonella-infected broilers, which were individually weighed weekly. Phage therapy did not affect the alpha or beta diversity of the microbiota. Specifically, we observed changes in the relative abundance of 14 out of the 110 genera using the PLS-DA and Bayes approaches. On the other hand, we noted changes in the caecal metabolites (63 up-accumulated and 37 down-accumulated out of the 1113 caecal metabolites). Nevertheless, the minimal changes in blood serum suggest a non-significant physiological response. The application of Salmonella phages under production conditions modulates the caecal microbiome and metabolome profiles in broilers without impacting the host physiology in terms of growth performance." @default.
- W4387653460 created "2023-10-16" @default.
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- W4387653460 date "2023-10-15" @default.
- W4387653460 modified "2023-10-16" @default.
- W4387653460 title "Modulation of Caecal Microbiota and Metabolome Profile in Salmonella-Infected Broilers by Phage Therapy" @default.
- W4387653460 cites W1535455654 @default.
- W4387653460 cites W1992196067 @default.
- W4387653460 cites W2001265990 @default.
- W4387653460 cites W2002800162 @default.
- W4387653460 cites W2018707178 @default.
- W4387653460 cites W2026733066 @default.
- W4387653460 cites W2034285706 @default.
- W4387653460 cites W2039684887 @default.
- W4387653460 cites W2062551369 @default.
- W4387653460 cites W2064214240 @default.
- W4387653460 cites W2115701239 @default.
- W4387653460 cites W2146522318 @default.
- W4387653460 cites W2180726383 @default.
- W4387653460 cites W2212094453 @default.
- W4387653460 cites W2224386098 @default.
- W4387653460 cites W2296724767 @default.
- W4387653460 cites W2401222577 @default.
- W4387653460 cites W2463118776 @default.
- W4387653460 cites W2507211052 @default.
- W4387653460 cites W2530081722 @default.
- W4387653460 cites W2533199225 @default.
- W4387653460 cites W2567040191 @default.
- W4387653460 cites W2588400683 @default.
- W4387653460 cites W2601204384 @default.
- W4387653460 cites W2739268225 @default.
- W4387653460 cites W2752159920 @default.
- W4387653460 cites W2753995775 @default.
- W4387653460 cites W2756772621 @default.
- W4387653460 cites W2757057836 @default.
- W4387653460 cites W2769152635 @default.
- W4387653460 cites W2772947478 @default.
- W4387653460 cites W2789399266 @default.
- W4387653460 cites W2807397898 @default.
- W4387653460 cites W2810810993 @default.
- W4387653460 cites W2889185703 @default.
- W4387653460 cites W2889310917 @default.
- W4387653460 cites W2894388498 @default.
- W4387653460 cites W2905810822 @default.
- W4387653460 cites W2941135962 @default.
- W4387653460 cites W2945425561 @default.
- W4387653460 cites W2948347995 @default.
- W4387653460 cites W2953403351 @default.
- W4387653460 cites W2964571155 @default.
- W4387653460 cites W2967288834 @default.
- W4387653460 cites W2972908879 @default.
- W4387653460 cites W2989988839 @default.
- W4387653460 cites W2990533513 @default.
- W4387653460 cites W2996092455 @default.
- W4387653460 cites W2997383678 @default.
- W4387653460 cites W3013964851 @default.
- W4387653460 cites W3025279022 @default.
- W4387653460 cites W3025763573 @default.
- W4387653460 cites W3033182537 @default.
- W4387653460 cites W3057268210 @default.
- W4387653460 cites W3088519169 @default.
- W4387653460 cites W3103375792 @default.
- W4387653460 cites W3120564666 @default.
- W4387653460 cites W3121499067 @default.
- W4387653460 cites W3122981388 @default.
- W4387653460 cites W3123037933 @default.
- W4387653460 cites W3125841184 @default.
- W4387653460 cites W3152442338 @default.
- W4387653460 cites W3159703051 @default.
- W4387653460 cites W3170150555 @default.
- W4387653460 cites W3182643237 @default.
- W4387653460 cites W3196329170 @default.
- W4387653460 cites W3197900115 @default.
- W4387653460 cites W3204346731 @default.
- W4387653460 cites W3205642313 @default.
- W4387653460 cites W3213792666 @default.
- W4387653460 cites W3214847187 @default.
- W4387653460 cites W3215581675 @default.
- W4387653460 cites W4200000976 @default.
- W4387653460 cites W4205807843 @default.
- W4387653460 cites W4206113838 @default.
- W4387653460 cites W4206564031 @default.
- W4387653460 cites W4206773588 @default.
- W4387653460 cites W4210322961 @default.
- W4387653460 cites W4210562301 @default.
- W4387653460 cites W4220938887 @default.
- W4387653460 cites W4224286994 @default.
- W4387653460 cites W4281258961 @default.
- W4387653460 cites W4281261240 @default.