Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387653864> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4387653864 endingPage "1596" @default.
- W4387653864 startingPage "1596" @default.
- W4387653864 abstract "The Influenza A virus of swine (IAV-S) is highly prevalent and causes significant economic losses to swine producers. Due to the highly variable and rapidly evolving nature of the virus, it is critical to develop a safe and versatile vaccine platform that allows for frequent updates of the vaccine immunogens to cope with the emergence of new viral strains. The main objective of this study was to assess the feasibility of using lipid nanoparticles (LNPs) as nanocarriers for delivering DNA plasmid encoding the viral hemagglutinin (HA) gene in pigs. The intramuscular administration of a single dose of the LNP-DNA vaccines resulted in robust systemic and mucosal responses in pigs. Importantly, the vaccinated pigs were fully protected against challenge infection with the homologous IAV-S strain, with only 1 out of 12 vaccinated pigs shedding a low amount of viral genomic RNA in its nasal cavity. No gross or microscopic lesions were observed in the lungs of the vaccinated pigs at necropsy. Thus, the LNP-DNA vaccines are highly effective in protecting pigs against the homologous IAV-S strain and can serve as a promising platform for the rapid development of IAV-S vaccines." @default.
- W4387653864 created "2023-10-16" @default.
- W4387653864 creator A5031221733 @default.
- W4387653864 creator A5046486979 @default.
- W4387653864 creator A5069172024 @default.
- W4387653864 creator A5070714608 @default.
- W4387653864 creator A5075739451 @default.
- W4387653864 creator A5080213723 @default.
- W4387653864 date "2023-10-15" @default.
- W4387653864 modified "2023-10-16" @default.
- W4387653864 title "A Single-Dose Intramuscular Immunization of Pigs with Lipid Nanoparticle DNA Vaccines Based on the Hemagglutinin Antigen Confers Complete Protection against Challenge Infection with the Homologous Influenza Virus Strain" @default.
- W4387653864 cites W1739247159 @default.
- W4387653864 cites W2002978200 @default.
- W4387653864 cites W2028348667 @default.
- W4387653864 cites W2037809757 @default.
- W4387653864 cites W2044470080 @default.
- W4387653864 cites W2056005257 @default.
- W4387653864 cites W2066738380 @default.
- W4387653864 cites W2106389211 @default.
- W4387653864 cites W2129971249 @default.
- W4387653864 cites W2140296277 @default.
- W4387653864 cites W2285881370 @default.
- W4387653864 cites W2401820295 @default.
- W4387653864 cites W2563295531 @default.
- W4387653864 cites W2769078947 @default.
- W4387653864 cites W2976361257 @default.
- W4387653864 cites W2979654866 @default.
- W4387653864 cites W3004277846 @default.
- W4387653864 cites W3045693155 @default.
- W4387653864 cites W3047091198 @default.
- W4387653864 cites W3103321439 @default.
- W4387653864 cites W4229364634 @default.
- W4387653864 cites W4283803576 @default.
- W4387653864 cites W4293724101 @default.
- W4387653864 cites W4306836145 @default.
- W4387653864 cites W4307842651 @default.
- W4387653864 cites W9551365 @default.
- W4387653864 doi "https://doi.org/10.3390/vaccines11101596" @default.
- W4387653864 hasPublicationYear "2023" @default.
- W4387653864 type Work @default.
- W4387653864 citedByCount "0" @default.
- W4387653864 crossrefType "journal-article" @default.
- W4387653864 hasAuthorship W4387653864A5031221733 @default.
- W4387653864 hasAuthorship W4387653864A5046486979 @default.
- W4387653864 hasAuthorship W4387653864A5069172024 @default.
- W4387653864 hasAuthorship W4387653864A5070714608 @default.
- W4387653864 hasAuthorship W4387653864A5075739451 @default.
- W4387653864 hasAuthorship W4387653864A5080213723 @default.
- W4387653864 hasBestOaLocation W43876538641 @default.
- W4387653864 hasConcept C104317684 @default.
- W4387653864 hasConcept C147483822 @default.
- W4387653864 hasConcept C159047783 @default.
- W4387653864 hasConcept C167508917 @default.
- W4387653864 hasConcept C203014093 @default.
- W4387653864 hasConcept C2522874641 @default.
- W4387653864 hasConcept C2777546802 @default.
- W4387653864 hasConcept C2778692840 @default.
- W4387653864 hasConcept C2780801004 @default.
- W4387653864 hasConcept C54355233 @default.
- W4387653864 hasConcept C64894306 @default.
- W4387653864 hasConcept C71924100 @default.
- W4387653864 hasConcept C86803240 @default.
- W4387653864 hasConceptScore W4387653864C104317684 @default.
- W4387653864 hasConceptScore W4387653864C147483822 @default.
- W4387653864 hasConceptScore W4387653864C159047783 @default.
- W4387653864 hasConceptScore W4387653864C167508917 @default.
- W4387653864 hasConceptScore W4387653864C203014093 @default.
- W4387653864 hasConceptScore W4387653864C2522874641 @default.
- W4387653864 hasConceptScore W4387653864C2777546802 @default.
- W4387653864 hasConceptScore W4387653864C2778692840 @default.
- W4387653864 hasConceptScore W4387653864C2780801004 @default.
- W4387653864 hasConceptScore W4387653864C54355233 @default.
- W4387653864 hasConceptScore W4387653864C64894306 @default.
- W4387653864 hasConceptScore W4387653864C71924100 @default.
- W4387653864 hasConceptScore W4387653864C86803240 @default.
- W4387653864 hasFunder F4320306114 @default.
- W4387653864 hasIssue "10" @default.
- W4387653864 hasLocation W43876538641 @default.
- W4387653864 hasOpenAccess W4387653864 @default.
- W4387653864 hasPrimaryLocation W43876538641 @default.
- W4387653864 hasRelatedWork W1556716938 @default.
- W4387653864 hasRelatedWork W2013097789 @default.
- W4387653864 hasRelatedWork W2053098560 @default.
- W4387653864 hasRelatedWork W2336164517 @default.
- W4387653864 hasRelatedWork W2383528274 @default.
- W4387653864 hasRelatedWork W2717892020 @default.
- W4387653864 hasRelatedWork W2949346453 @default.
- W4387653864 hasRelatedWork W3030201000 @default.
- W4387653864 hasRelatedWork W4283763648 @default.
- W4387653864 hasRelatedWork W4380729957 @default.
- W4387653864 hasVolume "11" @default.
- W4387653864 isParatext "false" @default.
- W4387653864 isRetracted "false" @default.
- W4387653864 workType "article" @default.