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• W4387654009 abstract "Abstract Background The effective regimen is lacking in areas with high antibiotic resistance and tetracycline unavailable. Whether minocycline can replace tetracycline for Helicobacter pylori eradication is unknown. This meta‐analysis compared and summarized the efficacy and safety profiles of H. pylori quadruple regimens with and without minocycline. Materials and Methods We conducted a literature search for regimens including minocycline quadruple therapy for H. pylori eradication and adverse events (AEs). Controls were patients undergoing any other treatment without minocycline. Searches were performed up to July 20, 2023, using PubMed and the Cochrane library. Results A total of five randomized controlled clinical trials with 2004 patients were included in this meta‐analysis. The H. pylori eradication rate of minocycline quadruple therapy was similar with that of control therapy (83.8% vs. 80.6%, OR 1.25, 95% CI [0.99–1.57], I 2 = 0%, p = 0.06) in ITT analysis. When treatment regimens with minocycline were compared only with treatment regimens with tetracycline, no significant difference was found in eradication rate:85.5% vs. 85.5%, OR 1.00, 95% CI 0.67–1.47, p = 1.00. But when treatment regimens with minocycline were compared with treatment regimens without tetracycline, the former was significantly superiority to the latter (82.7% vs. 77.2%; OR, 1.40, 95% CI 1.06–1.87, p = 0.02). The incidence of AEs in the quadruple therapy with minocycline group was similar with the control group (35.9% vs. 38.8%, OR 0.88, 95% CI [0.73–1.06], I 2 = 13%, p = 0.17). Conclusions We demonstrated the H. pylori eradication effect of minocycline quadruple therapy, and it might be an optional therapy. The safety of regimens containing minocycline was relatively satisfactory." @default.
• W4387654009 created "2023-10-16" @default.
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• W4387654009 date "2023-10-15" @default.
• W4387654009 modified "2023-10-17" @default.
• W4387654009 title "Efficacy and safety of minocycline quadruple therapy for Helicobacter pylori eradication: A meta‐analysis of <scp>RCTs</scp>" @default.
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• W4387654009 doi "https://doi.org/10.1111/hel.13022" @default.
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