Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387654641> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4387654641 abstract "Introduction Immune checkpoint inhibitors (ICIs) have revolutionized the management of multiple cancers over the last decade. They work by employing the immune system and exhibiting activity over T cells resulting in immune upregulation. Despite their widespread use, they produce side effects that can limit their use. The immune-related adverse events (irAEs) can be sometimes significant. The irAEs caused by ICIs may occur at any time during the treatment and can vary in grade (G). We sought to study the prevalence and toxicity patterns of ICIs in Oman. Methods One hundred forty-one adult patients (≥18 years) who received at least one dose of nivolumab, pembrolizumab, atezolizumab, or durvalumab between 2016 and 2022 were included. The data were analyzed retrospectively using univariable and multiple-variable logistic regressions. The Wilcoxon rank-sum test and Cochran-Armitage trend test were also used to summarize the continuous and ordinal data. Results Out of the 141 patients, 80 patients (56.7%) received pembrolizumab, and 48 (34%) received nivolumab. Common irAEs included endocrine abnormalities, pneumonitis, and colitis. Thirty patients (21.3%) experienced varying irAE grade toxicity. Out of the 30, 23 patients (82%) developed grade 2 and 3 irAEs. Discussion Predictive analysis showed that male sex and lower hemoglobin (Hb) and bilirubin levels were all significant predictors (p < 0.05) when associated with irAE occurrence. The prevalence of irAEs was similar compared to other reports, literature reviews, or meta-analyses. Female sex has been mentioned previously also to be a predictive factor for endocrine-related toxicities." @default.
- W4387654641 created "2023-10-16" @default.
- W4387654641 creator A5005881789 @default.
- W4387654641 creator A5031640269 @default.
- W4387654641 creator A5032823289 @default.
- W4387654641 creator A5064247554 @default.
- W4387654641 creator A5080357665 @default.
- W4387654641 creator A5093066886 @default.
- W4387654641 date "2023-10-15" @default.
- W4387654641 modified "2023-10-16" @default.
- W4387654641 title "The Prevalence and Patterns of Toxicity With Immune Checkpoint Inhibitors in Solid Tumors: A Real-World Experience From a Tertiary Care Center in Oman" @default.
- W4387654641 cites W1998491010 @default.
- W4387654641 cites W2527905628 @default.
- W4387654641 cites W2736166064 @default.
- W4387654641 cites W2743419024 @default.
- W4387654641 cites W2752227448 @default.
- W4387654641 cites W2783137027 @default.
- W4387654641 cites W2786816161 @default.
- W4387654641 cites W2891536507 @default.
- W4387654641 cites W2915015601 @default.
- W4387654641 cites W2945590213 @default.
- W4387654641 cites W2984466790 @default.
- W4387654641 cites W2988124258 @default.
- W4387654641 cites W2989956470 @default.
- W4387654641 cites W3000398809 @default.
- W4387654641 cites W3010839046 @default.
- W4387654641 cites W3016525073 @default.
- W4387654641 cites W3036175959 @default.
- W4387654641 cites W3041772936 @default.
- W4387654641 cites W3090325325 @default.
- W4387654641 cites W3100730147 @default.
- W4387654641 cites W3126377118 @default.
- W4387654641 cites W3172914666 @default.
- W4387654641 cites W3200724207 @default.
- W4387654641 cites W3204849024 @default.
- W4387654641 cites W4210573911 @default.
- W4387654641 cites W4220950491 @default.
- W4387654641 cites W4226360696 @default.
- W4387654641 cites W4282914332 @default.
- W4387654641 cites W4285742057 @default.
- W4387654641 cites W4306969508 @default.
- W4387654641 doi "https://doi.org/10.7759/cureus.47050" @default.
- W4387654641 hasPublicationYear "2023" @default.
- W4387654641 type Work @default.
- W4387654641 citedByCount "0" @default.
- W4387654641 crossrefType "journal-article" @default.
- W4387654641 hasAuthorship W4387654641A5005881789 @default.
- W4387654641 hasAuthorship W4387654641A5031640269 @default.
- W4387654641 hasAuthorship W4387654641A5032823289 @default.
- W4387654641 hasAuthorship W4387654641A5064247554 @default.
- W4387654641 hasAuthorship W4387654641A5080357665 @default.
- W4387654641 hasAuthorship W4387654641A5093066886 @default.
- W4387654641 hasBestOaLocation W43876546411 @default.
- W4387654641 hasConcept C121608353 @default.
- W4387654641 hasConcept C126322002 @default.
- W4387654641 hasConcept C197934379 @default.
- W4387654641 hasConcept C2775949291 @default.
- W4387654641 hasConcept C2776551883 @default.
- W4387654641 hasConcept C2777701055 @default.
- W4387654641 hasConcept C2777714996 @default.
- W4387654641 hasConcept C2777742743 @default.
- W4387654641 hasConcept C2779524853 @default.
- W4387654641 hasConcept C2780030458 @default.
- W4387654641 hasConcept C2780057760 @default.
- W4387654641 hasConcept C2780192828 @default.
- W4387654641 hasConcept C61367390 @default.
- W4387654641 hasConcept C71924100 @default.
- W4387654641 hasConceptScore W4387654641C121608353 @default.
- W4387654641 hasConceptScore W4387654641C126322002 @default.
- W4387654641 hasConceptScore W4387654641C197934379 @default.
- W4387654641 hasConceptScore W4387654641C2775949291 @default.
- W4387654641 hasConceptScore W4387654641C2776551883 @default.
- W4387654641 hasConceptScore W4387654641C2777701055 @default.
- W4387654641 hasConceptScore W4387654641C2777714996 @default.
- W4387654641 hasConceptScore W4387654641C2777742743 @default.
- W4387654641 hasConceptScore W4387654641C2779524853 @default.
- W4387654641 hasConceptScore W4387654641C2780030458 @default.
- W4387654641 hasConceptScore W4387654641C2780057760 @default.
- W4387654641 hasConceptScore W4387654641C2780192828 @default.
- W4387654641 hasConceptScore W4387654641C61367390 @default.
- W4387654641 hasConceptScore W4387654641C71924100 @default.
- W4387654641 hasLocation W43876546411 @default.
- W4387654641 hasOpenAccess W4387654641 @default.
- W4387654641 hasPrimaryLocation W43876546411 @default.
- W4387654641 hasRelatedWork W2473036963 @default.
- W4387654641 hasRelatedWork W2504822853 @default.
- W4387654641 hasRelatedWork W2734670400 @default.
- W4387654641 hasRelatedWork W2884534038 @default.
- W4387654641 hasRelatedWork W2898179151 @default.
- W4387654641 hasRelatedWork W2969038597 @default.
- W4387654641 hasRelatedWork W2982865941 @default.
- W4387654641 hasRelatedWork W3203586559 @default.
- W4387654641 hasRelatedWork W3210901691 @default.
- W4387654641 hasRelatedWork W4386284132 @default.
- W4387654641 isParatext "false" @default.
- W4387654641 isRetracted "false" @default.
- W4387654641 workType "article" @default.