Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387656000> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4387656000 endingPage "56" @default.
- W4387656000 startingPage "47" @default.
- W4387656000 abstract "Vanadium is a ubiquitous transition metal that has been generating contrasting research interest. Therapeutically, vanadium possess antidiabetic, antitumor, antiparasitic and even neuroprotective activities. On the flip side, vanadium has been reported to cause multisystemic toxicities with a strong predilection for the nervous system. Despite several reports on potential benefits of low-dose vanadium (LDV) and toxic effects of high-dose vanadium (HDV), there are no comparative studies done thus far. This study therefore explored the comparative effects of LDV and HDV exposure in mice during postnatal development. A total of nine (9) nursing mice were used in this study; with three nursing mice and their pups (n = 12 pups per group) randomly assigned to each of the three test groups. The nursing dam were given intraperitoneal (i.p) injection of vanadium at 0.15mg/kg and 3mg/kg for LDV and HDV respectively, and subseqently to the pups from postnatal day (PND) 15 till sacrifice on PND 90. We discovered that neurodevelopmental motor function test of mice-pups exposed to LDV here showed improved motor development, muscular strength and memory capacities whereas HDV led to motor function impairment, reduced muscular strength and memory capacities. LDV-exposed mice showed mild histological lesions in cerebral cortex whereas high-dose showed distinct histological lesions in different parts of the brain ranging from cerebellar Purkinje neuronal pathology (central chromatolysis), pyramidal neuronal loss in CA1 region, architectural distortion as well as fewer neurons in olfactory bulb. We saw mild lesions with LDV in both liver and kidney, however, with HDV exposure, there was diffuse hepatocellular vacuolar degeneration and congestion of blood vessels in liver, shrinkage of renal glomerulus and degenerated epithelial cells of kidney. Conclusively, beneficial effect of vanadium is proven as it facilitated body weight gain which translate in organ weight at low-dose, while high-dose caused decreased neurobehaviour and histological lesions." @default.
- W4387656000 created "2023-10-16" @default.
- W4387656000 creator A5066112777 @default.
- W4387656000 creator A5072809757 @default.
- W4387656000 creator A5079657245 @default.
- W4387656000 creator A5079918550 @default.
- W4387656000 creator A5082118181 @default.
- W4387656000 creator A5085044526 @default.
- W4387656000 date "2023-05-30" @default.
- W4387656000 modified "2023-10-16" @default.
- W4387656000 title "Neurobehavioural and Histological Study of the Effects of Low-Dose and High-Dose Vanadium in Brain, Liver and Kidney of Mice" @default.
- W4387656000 doi "https://doi.org/10.54548/njps.v38i1.8" @default.
- W4387656000 hasPublicationYear "2023" @default.
- W4387656000 type Work @default.
- W4387656000 citedByCount "0" @default.
- W4387656000 crossrefType "journal-article" @default.
- W4387656000 hasAuthorship W4387656000A5066112777 @default.
- W4387656000 hasAuthorship W4387656000A5072809757 @default.
- W4387656000 hasAuthorship W4387656000A5079657245 @default.
- W4387656000 hasAuthorship W4387656000A5079918550 @default.
- W4387656000 hasAuthorship W4387656000A5082118181 @default.
- W4387656000 hasAuthorship W4387656000A5085044526 @default.
- W4387656000 hasBestOaLocation W43876560001 @default.
- W4387656000 hasConcept C126322002 @default.
- W4387656000 hasConcept C134018914 @default.
- W4387656000 hasConcept C142724271 @default.
- W4387656000 hasConcept C169760540 @default.
- W4387656000 hasConcept C179104552 @default.
- W4387656000 hasConcept C185592680 @default.
- W4387656000 hasConcept C201792869 @default.
- W4387656000 hasConcept C25498285 @default.
- W4387656000 hasConcept C2778654693 @default.
- W4387656000 hasConcept C2780496858 @default.
- W4387656000 hasConcept C2780775167 @default.
- W4387656000 hasConcept C42407357 @default.
- W4387656000 hasConcept C504678139 @default.
- W4387656000 hasConcept C529278444 @default.
- W4387656000 hasConcept C70241572 @default.
- W4387656000 hasConcept C71924100 @default.
- W4387656000 hasConcept C86803240 @default.
- W4387656000 hasConceptScore W4387656000C126322002 @default.
- W4387656000 hasConceptScore W4387656000C134018914 @default.
- W4387656000 hasConceptScore W4387656000C142724271 @default.
- W4387656000 hasConceptScore W4387656000C169760540 @default.
- W4387656000 hasConceptScore W4387656000C179104552 @default.
- W4387656000 hasConceptScore W4387656000C185592680 @default.
- W4387656000 hasConceptScore W4387656000C201792869 @default.
- W4387656000 hasConceptScore W4387656000C25498285 @default.
- W4387656000 hasConceptScore W4387656000C2778654693 @default.
- W4387656000 hasConceptScore W4387656000C2780496858 @default.
- W4387656000 hasConceptScore W4387656000C2780775167 @default.
- W4387656000 hasConceptScore W4387656000C42407357 @default.
- W4387656000 hasConceptScore W4387656000C504678139 @default.
- W4387656000 hasConceptScore W4387656000C529278444 @default.
- W4387656000 hasConceptScore W4387656000C70241572 @default.
- W4387656000 hasConceptScore W4387656000C71924100 @default.
- W4387656000 hasConceptScore W4387656000C86803240 @default.
- W4387656000 hasIssue "1" @default.
- W4387656000 hasLocation W43876560001 @default.
- W4387656000 hasOpenAccess W4387656000 @default.
- W4387656000 hasPrimaryLocation W43876560001 @default.
- W4387656000 hasRelatedWork W2020093956 @default.
- W4387656000 hasRelatedWork W2045914711 @default.
- W4387656000 hasRelatedWork W2060063624 @default.
- W4387656000 hasRelatedWork W2061825044 @default.
- W4387656000 hasRelatedWork W2072365414 @default.
- W4387656000 hasRelatedWork W2072856858 @default.
- W4387656000 hasRelatedWork W2099354507 @default.
- W4387656000 hasRelatedWork W2378430301 @default.
- W4387656000 hasRelatedWork W3032472908 @default.
- W4387656000 hasRelatedWork W4231815232 @default.
- W4387656000 hasVolume "38" @default.
- W4387656000 isParatext "false" @default.
- W4387656000 isRetracted "false" @default.
- W4387656000 workType "article" @default.