Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387660965> ?p ?o ?g. }
- W4387660965 abstract "Recently, an intestinal dysbiotic microbiota with enrichment in oral cavity bacteria has been described in colorectal cancer (CRC) patients. Here, we characterize and investigate one of these oral pathobionts, the Gram-positive anaerobic coccus Parvimonas micra. We identified two phylotypes (A and B) exhibiting different phenotypes and adhesion capabilities. We observed a strong association of phylotype A with CRC, with its higher abundance in feces and in tumoral tissue compared with the normal homologous colonic mucosa, which was associated with a distinct methylation status of patients. By developing an in vitro hypoxic co-culture system of human primary colonic cells with anaerobic bacteria, we show that P. micra phylotype A alters the DNA methylation profile promoters of key tumor-suppressor genes, oncogenes, and genes involved in epithelial-mesenchymal transition. In colonic mucosa of CRC patients carrying P. micra phylotype A, we found similar DNA methylation alterations, together with significant enrichment of differentially expressed genes in pathways involved in inflammation, cell adhesion, and regulation of actin cytoskeleton, providing evidence of P. micra's possible role in the carcinogenic process." @default.
- W4387660965 created "2023-10-17" @default.
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- W4387660965 date "2023-10-16" @default.
- W4387660965 modified "2023-10-17" @default.
- W4387660965 title "<i>Parvimonas micra</i> , an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes" @default.
- W4387660965 cites W1532810787 @default.
- W4387660965 cites W1934094702 @default.
- W4387660965 cites W1966553280 @default.
- W4387660965 cites W1978651682 @default.
- W4387660965 cites W1979994539 @default.
- W4387660965 cites W1987953497 @default.
- W4387660965 cites W1989337144 @default.
- W4387660965 cites W1993952805 @default.
- W4387660965 cites W2001258296 @default.
- W4387660965 cites W2002513358 @default.
- W4387660965 cites W2006292369 @default.
- W4387660965 cites W2006663505 @default.
- W4387660965 cites W2010940056 @default.
- W4387660965 cites W2016853666 @default.
- W4387660965 cites W2027024056 @default.
- W4387660965 cites W2034285706 @default.
- W4387660965 cites W2054929768 @default.
- W4387660965 cites W2056040742 @default.
- W4387660965 cites W2072090020 @default.
- W4387660965 cites W2075479850 @default.
- W4387660965 cites W2081653606 @default.
- W4387660965 cites W2091564291 @default.
- W4387660965 cites W2093133983 @default.
- W4387660965 cites W2093682844 @default.
- W4387660965 cites W2095335749 @default.
- W4387660965 cites W2101163066 @default.
- W4387660965 cites W2101565190 @default.
- W4387660965 cites W2104816934 @default.
- W4387660965 cites W2105502933 @default.
- W4387660965 cites W2121926852 @default.
- W4387660965 cites W2122673596 @default.
- W4387660965 cites W2125932918 @default.
- W4387660965 cites W2130725058 @default.
- W4387660965 cites W2131497592 @default.
- W4387660965 cites W2133465414 @default.
- W4387660965 cites W2137526110 @default.
- W4387660965 cites W2138207763 @default.
- W4387660965 cites W2141224543 @default.
- W4387660965 cites W2146512944 @default.
- W4387660965 cites W2148908418 @default.
- W4387660965 cites W2150194502 @default.
- W4387660965 cites W2158217645 @default.
- W4387660965 cites W2167279371 @default.
- W4387660965 cites W2169456326 @default.
- W4387660965 cites W2173732482 @default.
- W4387660965 cites W2177605184 @default.
- W4387660965 cites W2178425989 @default.
- W4387660965 cites W2206368938 @default.
- W4387660965 cites W2262330054 @default.
- W4387660965 cites W2298959071 @default.
- W4387660965 cites W2307660471 @default.
- W4387660965 cites W2310046094 @default.
- W4387660965 cites W2314413252 @default.
- W4387660965 cites W2432815617 @default.
- W4387660965 cites W2465681871 @default.
- W4387660965 cites W2566227895 @default.
- W4387660965 cites W2567027391 @default.
- W4387660965 cites W2592578600 @default.
- W4387660965 cites W2603154743 @default.
- W4387660965 cites W2622608876 @default.
- W4387660965 cites W2770639073 @default.
- W4387660965 cites W2796331245 @default.
- W4387660965 cites W2800692603 @default.
- W4387660965 cites W2950036522 @default.
- W4387660965 cites W2950245396 @default.
- W4387660965 cites W2956307234 @default.
- W4387660965 cites W2969617932 @default.
- W4387660965 cites W2972666844 @default.
- W4387660965 cites W2972909175 @default.
- W4387660965 cites W2983898627 @default.
- W4387660965 cites W2984618995 @default.
- W4387660965 cites W2995930867 @default.
- W4387660965 cites W2997022986 @default.
- W4387660965 cites W3008359597 @default.
- W4387660965 cites W3042467811 @default.
- W4387660965 cites W3096828292 @default.
- W4387660965 cites W3099018540 @default.
- W4387660965 cites W4220684620 @default.
- W4387660965 cites W4237489130 @default.
- W4387660965 cites W4288177906 @default.