FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387661027> ?p ?o ?g. }

• W4387661027 abstract "Despite molecular selection, patients (pts) with RAS wildtype mCRC represent a heterogeneous population including diversity in metastatic spread. We investigated metastatic patterns for their prognostic and predictive impact on maintenance therapy with 5-fluorouracil/folinic acid ± panitumumab. The study population was stratified according to (1) number of involved metastatic sites (single vs multiple organ metastasis), liver-limited disease vs (2) liver metastasis plus one additional site, and (3) vs liver metastasis plus ≥two additional sites. Kaplan-Meier method and Cox regressions were used to correlate efficacy endpoints. Single organ metastasis was observed in 133 pts (53.6%) with 102 pts (41.1%) presenting with liver-limited disease, while multiple organ metastases were reported in 114 pts (46.0). Multiple compared to single organ metastases were associated with less favorable PFS (HR 1.48, 95% CI 1.13-1.93; P = .004) and OS (HR 1.37, 95% CI 0.98-1.93; P = .068) of maintenance therapy. While metastatic spread involving one additional extrahepatic site was not associated with clearly impaired survival compared to liver-limited disease, pts with liver metastasis plus ≥two additional sites demonstrated less favorable PFS (HR 1.92, 95% CI 1.30-2.83; P < .001), and OS (HR 2.38, 95% CI 1.51-3.76; P < .001) of maintenance therapy. Pmab-containing maintenance therapy appeared active in both pts with multiple (HR 0.58; 95% CI, 0.39-0.86; P = .006) as well as to a lesser numerical extent in pts with single organ metastasis (HR 0.83; 95% CI, 0.57-1.21; P = .332; Interaction P = .183). These data may support clinical decisions when EGFR-based maintenance therapy is considered." @default.
• W4387661027 created "2023-10-17" @default.
• W4387661027 creator A5012380788 @default.
• W4387661027 creator A5013028677 @default.
• W4387661027 creator A5016774223 @default.
• W4387661027 creator A5028841026 @default.
• W4387661027 creator A5028938155 @default.
• W4387661027 creator A5037011093 @default.
• W4387661027 creator A5037696803 @default.
• W4387661027 creator A5039743409 @default.
• W4387661027 creator A5055703322 @default.
• W4387661027 creator A5055766851 @default.
• W4387661027 creator A5061986111 @default.
• W4387661027 creator A5063940692 @default.
• W4387661027 creator A5067138413 @default.
• W4387661027 creator A5069246337 @default.
• W4387661027 creator A5069585976 @default.
• W4387661027 creator A5077797736 @default.
• W4387661027 creator A5085332368 @default.
• W4387661027 creator A5091140526 @default.
• W4387661027 creator A5091422927 @default.
• W4387661027 creator A5092083501 @default.
• W4387661027 date "2023-10-15" @default.
• W4387661027 modified "2023-10-17" @default.
• W4387661027 title "Prognostic and predictive impact of metastatic organ involvement on maintenance therapy in advanced metastatic colorectal cancer: Subgroup analysis of patients treated within the <scp>PanaMa</scp> trial (<scp>AIO KRK</scp> 0212)" @default.
• W4387661027 cites W1984276780 @default.
• W4387661027 cites W1992421431 @default.
• W4387661027 cites W1995680367 @default.
• W4387661027 cites W2019607817 @default.
• W4387661027 cites W2039648924 @default.
• W4387661027 cites W2051426959 @default.
• W4387661027 cites W2058946786 @default.
• W4387661027 cites W2089300758 @default.
• W4387661027 cites W2118971132 @default.
• W4387661027 cites W2137417501 @default.
• W4387661027 cites W2138235363 @default.
• W4387661027 cites W2153211112 @default.
• W4387661027 cites W2162278616 @default.
• W4387661027 cites W2168460655 @default.
• W4387661027 cites W2253395177 @default.
• W4387661027 cites W2254775005 @default.
• W4387661027 cites W2339072493 @default.
• W4387661027 cites W2395807466 @default.
• W4387661027 cites W2470575266 @default.
• W4387661027 cites W2531203326 @default.
• W4387661027 cites W2558788971 @default.
• W4387661027 cites W2586166317 @default.
• W4387661027 cites W2605964154 @default.
• W4387661027 cites W2609363527 @default.
• W4387661027 cites W2744203203 @default.
• W4387661027 cites W2783686102 @default.
• W4387661027 cites W2808169264 @default.
• W4387661027 cites W2883387786 @default.
• W4387661027 cites W2957606247 @default.
• W4387661027 cites W2965553819 @default.
• W4387661027 cites W2984360057 @default.
• W4387661027 cites W3177402682 @default.
• W4387661027 cites W4214758057 @default.
• W4387661027 cites W4225850943 @default.
• W4387661027 cites W4226248999 @default.
• W4387661027 cites W4307401860 @default.
• W4387661027 doi "https://doi.org/10.1002/ijc.34760" @default.
• W4387661027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37840339" @default.
• W4387661027 hasPublicationYear "2023" @default.
• W4387661027 type Work @default.
• W4387661027 citedByCount "0" @default.
• W4387661027 crossrefType "journal-article" @default.
• W4387661027 hasAuthorship W4387661027A5012380788 @default.
• W4387661027 hasAuthorship W4387661027A5013028677 @default.
• W4387661027 hasAuthorship W4387661027A5016774223 @default.
• W4387661027 hasAuthorship W4387661027A5028841026 @default.
• W4387661027 hasAuthorship W4387661027A5028938155 @default.
• W4387661027 hasAuthorship W4387661027A5037011093 @default.
• W4387661027 hasAuthorship W4387661027A5037696803 @default.
• W4387661027 hasAuthorship W4387661027A5039743409 @default.
• W4387661027 hasAuthorship W4387661027A5055703322 @default.
• W4387661027 hasAuthorship W4387661027A5055766851 @default.
• W4387661027 hasAuthorship W4387661027A5061986111 @default.
• W4387661027 hasAuthorship W4387661027A5063940692 @default.
• W4387661027 hasAuthorship W4387661027A5067138413 @default.
• W4387661027 hasAuthorship W4387661027A5069246337 @default.
• W4387661027 hasAuthorship W4387661027A5069585976 @default.
• W4387661027 hasAuthorship W4387661027A5077797736 @default.
• W4387661027 hasAuthorship W4387661027A5085332368 @default.
• W4387661027 hasAuthorship W4387661027A5091140526 @default.
• W4387661027 hasAuthorship W4387661027A5091422927 @default.
• W4387661027 hasAuthorship W4387661027A5092083501 @default.
• W4387661027 hasBestOaLocation W43876610271 @default.
• W4387661027 hasConcept C121608353 @default.
• W4387661027 hasConcept C126322002 @default.
• W4387661027 hasConcept C143998085 @default.
• W4387661027 hasConcept C207103383 @default.
• W4387661027 hasConcept C2779013556 @default.
• W4387661027 hasConcept C2779804826 @default.
• W4387661027 hasConcept C2908647359 @default.
• W4387661027 hasConcept C44249647 @default.
• W4387661027 hasConcept C526805850 @default.
• W4387661027 hasConcept C71924100 @default.
• W4387661027 hasConcept C90924648 @default.
• W4387661027 hasConcept C99454951 @default.

• next