FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387661137> ?p ?o ?g. }

• W4387661137 abstract "Multiple sclerosis (MS) is a complex autoimmune condition affecting the central nervous system characterized by axonal damage, demyelination, and chronic inflammation. Multiple molecular and cellular components mediate neuroinflammation in MS. In human macrophages and microglia, miRNA-155 is an essential proinflammatory noncoding RNA that regulates phenotypic and functional polarization properties. This study was conducted to detect the plasma level of miRNA-155 in RRMS and assess its relationship with inflammatory and anti-inflammatory mediators. The study included 60 MS patients and 30 healthy controls. Real-time quantitative polymerase chain reaction was utilized to detect miRNA-155, iNOS, and SMAD2, whereas ELISA was used to determine TNF-α, IFN-ɣ, TGF-β, and IL-10 levels. There was no significant difference in miRNA-155, SMAD2, and iNOS expression in MS patients compared to control subjects. In addition, there was a statistically significant increase in TNF-α, INF-ɣ, and TGF-β levels. IL-10 levels did not differ significantly between MS patients and healthy controls. There was a positive correlation between miRNA-155 and TNF-α (p < 0.000, r = 0.922), INF-ɣ (p < 0.000, r = 0.81), and iNOS (p < 0.000, r = 0.916) and inverse correlation between miRNA-155 and IL-10 (p < 0.000, r = -0.928), TGF-β (p < 0.000, r = -0.904) and SMAD2 (p < 0.000, r = -0.848). We conclude that expression of miRNA-155 in MS may modulate macrophage/microglia polarization by increasing the secretion of TNF-α, IFN-ɣ & iNOS and decreasing anti-inflammatory mediators IL10 and TGF-β." @default.
• W4387661137 created "2023-10-17" @default.
• W4387661137 creator A5017340720 @default.
• W4387661137 creator A5069719894 @default.
• W4387661137 creator A5075047656 @default.
• W4387661137 creator A5084498875 @default.
• W4387661137 creator A5091070220 @default.
• W4387661137 creator A5091337099 @default.
• W4387661137 date "2023-10-16" @default.
• W4387661137 modified "2023-10-17" @default.
• W4387661137 title "Relation between microRNA‐155 and inflammatory mediators in multiple sclerosis" @default.
• W4387661137 cites W1664596139 @default.
• W4387661137 cites W1915908724 @default.
• W4387661137 cites W1971091263 @default.
• W4387661137 cites W1972725262 @default.
• W4387661137 cites W1987762357 @default.
• W4387661137 cites W1988768211 @default.
• W4387661137 cites W2001235261 @default.
• W4387661137 cites W2011769338 @default.
• W4387661137 cites W2016848669 @default.
• W4387661137 cites W2040981636 @default.
• W4387661137 cites W2040989443 @default.
• W4387661137 cites W2046508329 @default.
• W4387661137 cites W2050348658 @default.
• W4387661137 cites W2052644415 @default.
• W4387661137 cites W2060952934 @default.
• W4387661137 cites W2071753918 @default.
• W4387661137 cites W2079166304 @default.
• W4387661137 cites W2095876795 @default.
• W4387661137 cites W2106492904 @default.
• W4387661137 cites W2111607861 @default.
• W4387661137 cites W2127314160 @default.
• W4387661137 cites W2128640727 @default.
• W4387661137 cites W2143216993 @default.
• W4387661137 cites W2145233791 @default.
• W4387661137 cites W2150815423 @default.
• W4387661137 cites W2163106706 @default.
• W4387661137 cites W2574076923 @default.
• W4387661137 cites W2777074421 @default.
• W4387661137 cites W2791262814 @default.
• W4387661137 cites W2891421333 @default.
• W4387661137 cites W2902060738 @default.
• W4387661137 cites W2931348934 @default.
• W4387661137 cites W3198141140 @default.
• W4387661137 cites W394666387 @default.
• W4387661137 cites W647280284 @default.
• W4387661137 doi "https://doi.org/10.1002/jbt.23555" @default.
• W4387661137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37843075" @default.
• W4387661137 hasPublicationYear "2023" @default.
• W4387661137 type Work @default.
• W4387661137 citedByCount "0" @default.
• W4387661137 crossrefType "journal-article" @default.
• W4387661137 hasAuthorship W4387661137A5017340720 @default.
• W4387661137 hasAuthorship W4387661137A5069719894 @default.
• W4387661137 hasAuthorship W4387661137A5075047656 @default.
• W4387661137 hasAuthorship W4387661137A5084498875 @default.
• W4387661137 hasAuthorship W4387661137A5091070220 @default.
• W4387661137 hasAuthorship W4387661137A5091337099 @default.
• W4387661137 hasBestOaLocation W43876611371 @default.
• W4387661137 hasConcept C104317684 @default.
• W4387661137 hasConcept C118131993 @default.
• W4387661137 hasConcept C126322002 @default.
• W4387661137 hasConcept C145059251 @default.
• W4387661137 hasConcept C156730664 @default.
• W4387661137 hasConcept C164027704 @default.
• W4387661137 hasConcept C17991360 @default.
• W4387661137 hasConcept C187316574 @default.
• W4387661137 hasConcept C203014093 @default.
• W4387661137 hasConcept C2776914184 @default.
• W4387661137 hasConcept C2778455985 @default.
• W4387661137 hasConcept C2778690821 @default.
• W4387661137 hasConcept C2779830541 @default.
• W4387661137 hasConcept C2780640218 @default.
• W4387661137 hasConcept C47348012 @default.
• W4387661137 hasConcept C49039625 @default.
• W4387661137 hasConcept C54355233 @default.
• W4387661137 hasConcept C71924100 @default.
• W4387661137 hasConcept C86803240 @default.
• W4387661137 hasConcept C87753298 @default.
• W4387661137 hasConceptScore W4387661137C104317684 @default.
• W4387661137 hasConceptScore W4387661137C118131993 @default.
• W4387661137 hasConceptScore W4387661137C126322002 @default.
• W4387661137 hasConceptScore W4387661137C145059251 @default.
• W4387661137 hasConceptScore W4387661137C156730664 @default.
• W4387661137 hasConceptScore W4387661137C164027704 @default.
• W4387661137 hasConceptScore W4387661137C17991360 @default.
• W4387661137 hasConceptScore W4387661137C187316574 @default.
• W4387661137 hasConceptScore W4387661137C203014093 @default.
• W4387661137 hasConceptScore W4387661137C2776914184 @default.
• W4387661137 hasConceptScore W4387661137C2778455985 @default.
• W4387661137 hasConceptScore W4387661137C2778690821 @default.
• W4387661137 hasConceptScore W4387661137C2779830541 @default.
• W4387661137 hasConceptScore W4387661137C2780640218 @default.
• W4387661137 hasConceptScore W4387661137C47348012 @default.
• W4387661137 hasConceptScore W4387661137C49039625 @default.
• W4387661137 hasConceptScore W4387661137C54355233 @default.
• W4387661137 hasConceptScore W4387661137C71924100 @default.
• W4387661137 hasConceptScore W4387661137C86803240 @default.
• W4387661137 hasConceptScore W4387661137C87753298 @default.
• W4387661137 hasLocation W43876611371 @default.

• next