FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387661351> ?p ?o ?g. }

• W4387661351 abstract "Many medical experts prescribe indomethacin because of its anti-inflammatory, analgesic, tocolytic, and duct closure effects. This article presents an evaluation of the enduring impact of indomethacin on neonatal rats with hypoxic-ischemic (HI) insults, employing behavioral tests as a method of assessment.The experiment was conducted on male Wistar-Albino rats weighing 10 to 15 g, aged between seven and 10 days. The rats were divided into three groups using a random allocation method as follows: hypoxic ischemic encephalopathy (HIE) group, HIE treated with indomethacin group (INDO), and Sham group. A left common carotid artery ligation and hypoxia model was applied in both the HIE and INDO groups. The INDO group was treated with 4 mg/kg intraperitoneal indomethacin every 24 h for 3 days, while the Sham and HIE groups were given dimethylsulfoxide (DMSO). After 72 h, five rats from each group were sacrificed and brain tissue samples were stained with 2,3,5-Triphenyltetrazolium chloride (TCC) for infarct-volume measurement. Seven rats from each group were taken to the behavioral laboratory in the sixth postnatal week (PND42) and six from each group were sacrificed for the Evans blue (EB) experiment for blood-brain barrier (BBB) integrity evaluation. The open field (OF) test and Morris water maze (MWM) tests were performed. After behavioral tests, brain tissue were obtained and stained with TCC to assess the infarct volume.The significant increase in the time spent in the central area and the frequency of crossing to the center in the INDO group compared with the HIE group indicated that indomethacin decreased anxiety-like behavior (p < 0.001, p < 0.05). However, the MWM test revealed that indomethacin did not positively affect learning and memory performance (p > 0.05). Additionally, indomethacin significantly reduced infarct volume and neuropathological grading in adolescence (p < 0.05), although not statistically significant in the early period. Moreover, the EB experiment demonstrated that indomethacin effectively increased BBB integrity (p < 0.05).In this study, we have shown for the first time that indomethacin treatment can reduce levels of anxiety-like behavior and enhance levels of exploratory behavior in a neonatal rat model with HIE. It is necessary to determine whether nonsteroidal anti-inflammatory agents, such as indomethacin, should be used for adjuvant therapy in newborns with HIE." @default.
• W4387661351 created "2023-10-17" @default.
• W4387661351 creator A5006592586 @default.
• W4387661351 creator A5009709273 @default.
• W4387661351 creator A5018026134 @default.
• W4387661351 creator A5020751077 @default.
• W4387661351 creator A5024629643 @default.
• W4387661351 creator A5047210487 @default.
• W4387661351 creator A5050729006 @default.
• W4387661351 creator A5083789559 @default.
• W4387661351 creator A5086367788 @default.
• W4387661351 creator A5087636160 @default.
• W4387661351 date "2023-10-16" @default.
• W4387661351 modified "2023-10-17" @default.
• W4387661351 title "Long‐term effect of indomethacin on a rat model of neonatal hypoxia ischemic encephalopathy through behavioral tests" @default.
• W4387661351 cites W137139219 @default.
• W4387661351 cites W1578545245 @default.
• W4387661351 cites W1966037459 @default.
• W4387661351 cites W1967061503 @default.
• W4387661351 cites W1983479763 @default.
• W4387661351 cites W1999267303 @default.
• W4387661351 cites W2006593236 @default.
• W4387661351 cites W2008374247 @default.
• W4387661351 cites W2029885926 @default.
• W4387661351 cites W2029936414 @default.
• W4387661351 cites W2035895920 @default.
• W4387661351 cites W2044793350 @default.
• W4387661351 cites W2052634728 @default.
• W4387661351 cites W2069413340 @default.
• W4387661351 cites W2073788721 @default.
• W4387661351 cites W2075982837 @default.
• W4387661351 cites W2078284510 @default.
• W4387661351 cites W2099484254 @default.
• W4387661351 cites W2103580848 @default.
• W4387661351 cites W2108661935 @default.
• W4387661351 cites W2120631068 @default.
• W4387661351 cites W2121836743 @default.
• W4387661351 cites W2123355863 @default.
• W4387661351 cites W2134561732 @default.
• W4387661351 cites W2136000727 @default.
• W4387661351 cites W2136967026 @default.
• W4387661351 cites W2148809826 @default.
• W4387661351 cites W2149233326 @default.
• W4387661351 cites W2156675756 @default.
• W4387661351 cites W2158707363 @default.
• W4387661351 cites W2164163343 @default.
• W4387661351 cites W2258831804 @default.
• W4387661351 cites W2462384187 @default.
• W4387661351 cites W2532107706 @default.
• W4387661351 cites W2767223016 @default.
• W4387661351 cites W2778134206 @default.
• W4387661351 cites W2891493825 @default.
• W4387661351 cites W2938158554 @default.
• W4387661351 cites W2964295256 @default.
• W4387661351 cites W3006420505 @default.
• W4387661351 cites W3157163500 @default.
• W4387661351 cites W4233435953 @default.
• W4387661351 cites W4235060674 @default.
• W4387661351 cites W4246698602 @default.
• W4387661351 cites W4321258324 @default.
• W4387661351 doi "https://doi.org/10.1002/jdn.10305" @default.
• W4387661351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37842754" @default.
• W4387661351 hasPublicationYear "2023" @default.
• W4387661351 type Work @default.
• W4387661351 citedByCount "0" @default.
• W4387661351 crossrefType "journal-article" @default.
• W4387661351 hasAuthorship W4387661351A5006592586 @default.
• W4387661351 hasAuthorship W4387661351A5009709273 @default.
• W4387661351 hasAuthorship W4387661351A5018026134 @default.
• W4387661351 hasAuthorship W4387661351A5020751077 @default.
• W4387661351 hasAuthorship W4387661351A5024629643 @default.
• W4387661351 hasAuthorship W4387661351A5047210487 @default.
• W4387661351 hasAuthorship W4387661351A5050729006 @default.
• W4387661351 hasAuthorship W4387661351A5083789559 @default.
• W4387661351 hasAuthorship W4387661351A5086367788 @default.
• W4387661351 hasAuthorship W4387661351A5087636160 @default.
• W4387661351 hasConcept C126322002 @default.
• W4387661351 hasConcept C148762608 @default.
• W4387661351 hasConcept C178790620 @default.
• W4387661351 hasConcept C179437574 @default.
• W4387661351 hasConcept C185592680 @default.
• W4387661351 hasConcept C2777649898 @default.
• W4387661351 hasConcept C2778621155 @default.
• W4387661351 hasConcept C2909832856 @default.
• W4387661351 hasConcept C42219234 @default.
• W4387661351 hasConcept C44752575 @default.
• W4387661351 hasConcept C540031477 @default.
• W4387661351 hasConcept C71924100 @default.
• W4387661351 hasConcept C7836513 @default.
• W4387661351 hasConceptScore W4387661351C126322002 @default.
• W4387661351 hasConceptScore W4387661351C148762608 @default.
• W4387661351 hasConceptScore W4387661351C178790620 @default.
• W4387661351 hasConceptScore W4387661351C179437574 @default.
• W4387661351 hasConceptScore W4387661351C185592680 @default.
• W4387661351 hasConceptScore W4387661351C2777649898 @default.
• W4387661351 hasConceptScore W4387661351C2778621155 @default.
• W4387661351 hasConceptScore W4387661351C2909832856 @default.
• W4387661351 hasConceptScore W4387661351C42219234 @default.
• W4387661351 hasConceptScore W4387661351C44752575 @default.
• W4387661351 hasConceptScore W4387661351C540031477 @default.

• next