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- W4387661805 abstract "Non-coding microRNAs are powerful epigenetic regulators of cellular processes by their ability to target and suppress expression of numerous protein-coding mRNAs. This multi-targeting function is a unique and complex feature of microRNAs. It is now well-described that microRNAs play important roles in regulating the development and homeostasis of many cell/tissue types, including those that make up the skeletal system. In this review, we focus on microRNA-138 (miR-138) and its effects on regulating bone and cartilage cell differentiation and function. In addition to its reported role as a tumor suppressor, miR-138 appears to function as an inhibitor of osteoblast differentiation. This review provides additional information on studies that have attempted to alter miR-138 expression in vivo as a means to dampen ectopic calcification or alter bone mass. However, a review of the published literature on miR-138 in cartilage reveals a number of contradictory and inconclusive findings with respect to regulating chondrogenesis and chondrocyte catabolism. This highlights the need for more research in understanding the role of miR-138 in cartilage biology and disease. Interestingly, a number of studies in other systems have reported miR-138-mediated effects in dampening inflammation and pain responses. Future studies will reveal if a multi-functional role of miR-138 involving suppression of ectopic bone, inflammation and pain will be beneficial in skeletal conditions such as osteoarthritis and heterotopic ossification." @default.
- W4387661805 created "2023-10-17" @default.
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- W4387661805 date "2023-10-16" @default.
- W4387661805 modified "2023-10-17" @default.
- W4387661805 title "MicroRNA-138: An Emerging Regulator of Skeletal Development, Homeostasis and Disease" @default.
- W4387661805 doi "https://doi.org/10.1152/ajpcell.00382.2023" @default.
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- W4387661805 hasPublicationYear "2023" @default.
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