FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387665107> ?p ?o ?g. }

• W4387665107 abstract "Mutations in Leucine-rich repeat kinase 2 (LRRK2) are responsible for late-onset autosomal dominant Parkinson's disease. LRRK2 has been implicated in a wide range of physiological processes including membrane repair in the endolysosomal system. Here, using cell-free systems, we report that purified LRRK2 directly binds acidic lipid bilayers with a preference for highly curved bilayers. While this binding is nucleotide independent, LRRK2 can also deform low-curvature liposomes into narrow tubules in a guanylnucleotide-dependent but Adenosine 5'-triphosphate-independent way. Moreover, assembly of LRRK2 into scaffolds at the surface of lipid tubules can constrict them. We suggest that an interplay between the membrane remodeling and signaling properties of LRRK2 may be key to its physiological function. LRRK2, via its kinase activity, may achieve its signaling role at sites where membrane remodeling occurs." @default.
• W4387665107 created "2023-10-17" @default.
• W4387665107 creator A5004727785 @default.
• W4387665107 creator A5026423769 @default.
• W4387665107 creator A5036898198 @default.
• W4387665107 creator A5040142346 @default.
• W4387665107 creator A5059004341 @default.
• W4387665107 creator A5060299931 @default.
• W4387665107 creator A5079819407 @default.
• W4387665107 creator A5090536824 @default.
• W4387665107 date "2023-10-16" @default.
• W4387665107 modified "2023-10-18" @default.
• W4387665107 title "Membrane remodeling properties of the Parkinson’s disease protein LRRK2" @default.
• W4387665107 cites W1803692820 @default.
• W4387665107 cites W1970305282 @default.
• W4387665107 cites W1972812883 @default.
• W4387665107 cites W1973642611 @default.
• W4387665107 cites W1978627586 @default.
• W4387665107 cites W1981431290 @default.
• W4387665107 cites W1986744284 @default.
• W4387665107 cites W1995112887 @default.
• W4387665107 cites W2000678571 @default.
• W4387665107 cites W2001410943 @default.
• W4387665107 cites W2027670444 @default.
• W4387665107 cites W2042949114 @default.
• W4387665107 cites W2049315117 @default.
• W4387665107 cites W2055555352 @default.
• W4387665107 cites W2063127941 @default.
• W4387665107 cites W2071877471 @default.
• W4387665107 cites W2072167784 @default.
• W4387665107 cites W2099111846 @default.
• W4387665107 cites W2100300726 @default.
• W4387665107 cites W2100869615 @default.
• W4387665107 cites W2100894616 @default.
• W4387665107 cites W2125511222 @default.
• W4387665107 cites W2143369277 @default.
• W4387665107 cites W2157773619 @default.
• W4387665107 cites W2253950023 @default.
• W4387665107 cites W2593511418 @default.
• W4387665107 cites W2598217277 @default.
• W4387665107 cites W2752531558 @default.
• W4387665107 cites W2891994821 @default.
• W4387665107 cites W2944298433 @default.
• W4387665107 cites W2972937106 @default.
• W4387665107 cites W2980851597 @default.
• W4387665107 cites W2994847103 @default.
• W4387665107 cites W3004823952 @default.
• W4387665107 cites W3037536086 @default.
• W4387665107 cites W3040983129 @default.
• W4387665107 cites W3048909661 @default.
• W4387665107 cites W3068292362 @default.
• W4387665107 cites W3098923693 @default.
• W4387665107 cites W3165747523 @default.
• W4387665107 cites W3171048111 @default.
• W4387665107 cites W4280593294 @default.
• W4387665107 cites W4282914791 @default.
• W4387665107 cites W4290803974 @default.
• W4387665107 cites W4291001786 @default.
• W4387665107 cites W4293792769 @default.
• W4387665107 cites W4296793671 @default.
• W4387665107 cites W4306734767 @default.
• W4387665107 cites W4311901922 @default.
• W4387665107 cites W4321452446 @default.
• W4387665107 cites W4321490255 @default.
• W4387665107 doi "https://doi.org/10.1073/pnas.2309698120" @default.
• W4387665107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37844218" @default.
• W4387665107 hasPublicationYear "2023" @default.
• W4387665107 type Work @default.
• W4387665107 citedByCount "0" @default.
• W4387665107 crossrefType "journal-article" @default.
• W4387665107 hasAuthorship W4387665107A5004727785 @default.
• W4387665107 hasAuthorship W4387665107A5026423769 @default.
• W4387665107 hasAuthorship W4387665107A5036898198 @default.
• W4387665107 hasAuthorship W4387665107A5040142346 @default.
• W4387665107 hasAuthorship W4387665107A5059004341 @default.
• W4387665107 hasAuthorship W4387665107A5060299931 @default.
• W4387665107 hasAuthorship W4387665107A5079819407 @default.
• W4387665107 hasAuthorship W4387665107A5090536824 @default.
• W4387665107 hasBestOaLocation W43876651071 @default.
• W4387665107 hasConcept C104317684 @default.
• W4387665107 hasConcept C12554922 @default.
• W4387665107 hasConcept C184235292 @default.
• W4387665107 hasConcept C185592680 @default.
• W4387665107 hasConcept C2777278457 @default.
• W4387665107 hasConcept C2779564974 @default.
• W4387665107 hasConcept C2780427247 @default.
• W4387665107 hasConcept C39944091 @default.
• W4387665107 hasConcept C41625074 @default.
• W4387665107 hasConcept C501734568 @default.
• W4387665107 hasConcept C55493867 @default.
• W4387665107 hasConcept C62478195 @default.
• W4387665107 hasConcept C86803240 @default.
• W4387665107 hasConcept C95444343 @default.
• W4387665107 hasConcept C99545290 @default.
• W4387665107 hasConceptScore W4387665107C104317684 @default.
• W4387665107 hasConceptScore W4387665107C12554922 @default.
• W4387665107 hasConceptScore W4387665107C184235292 @default.
• W4387665107 hasConceptScore W4387665107C185592680 @default.
• W4387665107 hasConceptScore W4387665107C2777278457 @default.
• W4387665107 hasConceptScore W4387665107C2779564974 @default.

• next