Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387665956> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4387665956 abstract "Multimorbidity represents an increasingly important public health challenge with far-reaching implications for health management and policy. Mental health and metabolic diseases have a well-established epidemiological association. In this study, we investigate the genetic intersection between type 2 diabetes and schizophrenia. We use Mendelian randomization to examine potential causal relationships between the two conditions and related endophenotypes. We report no compelling evidence that type 2 diabetes genetic liability potentially causally influences schizophrenia risk and vice versa. Our findings show that increased body mass index (BMI) has a protective effect against schizophrenia, in contrast to the well-known risk-increasing effect of BMI on type 2 diabetes risk. We identify evidence of colocalization of association signals for these two conditions at 11 genomic loci, six of which have opposing directions of effect for type 2 diabetes and schizophrenia. To elucidate these colocalizing signals, we integrate multi-omics data from bulk and single-cell gene expression studies, along with functional information. We identify high-confidence effector genes and find that they are enriched for homeostasis and lipid-related pathways. We also highlight drug repurposing opportunities including N-methyl-D-aspartate (NMDA) receptor antagonists. Our findings provide insights into shared biological mechanisms for type 2 diabetes and schizophrenia, highlighting common factors that influence the risk of the two conditions in opposite directions and shedding light on the complex nature of this comorbidity." @default.
- W4387665956 created "2023-10-17" @default.
- W4387665956 creator A5006025541 @default.
- W4387665956 creator A5013080833 @default.
- W4387665956 creator A5013184354 @default.
- W4387665956 creator A5015682429 @default.
- W4387665956 creator A5025775908 @default.
- W4387665956 creator A5031210932 @default.
- W4387665956 date "2023-10-16" @default.
- W4387665956 modified "2023-10-17" @default.
- W4387665956 title "Genomic insights into the comorbidity between type 2 diabetes and schizophrenia." @default.
- W4387665956 doi "https://doi.org/10.1101/2023.10.16.23297073" @default.
- W4387665956 hasPublicationYear "2023" @default.
- W4387665956 type Work @default.
- W4387665956 citedByCount "0" @default.
- W4387665956 crossrefType "posted-content" @default.
- W4387665956 hasAuthorship W4387665956A5006025541 @default.
- W4387665956 hasAuthorship W4387665956A5013080833 @default.
- W4387665956 hasAuthorship W4387665956A5013184354 @default.
- W4387665956 hasAuthorship W4387665956A5015682429 @default.
- W4387665956 hasAuthorship W4387665956A5025775908 @default.
- W4387665956 hasAuthorship W4387665956A5031210932 @default.
- W4387665956 hasBestOaLocation W43876659561 @default.
- W4387665956 hasConcept C104317684 @default.
- W4387665956 hasConcept C106208931 @default.
- W4387665956 hasConcept C118552586 @default.
- W4387665956 hasConcept C134018914 @default.
- W4387665956 hasConcept C135763542 @default.
- W4387665956 hasConcept C153209595 @default.
- W4387665956 hasConcept C15744967 @default.
- W4387665956 hasConcept C169760540 @default.
- W4387665956 hasConcept C169900460 @default.
- W4387665956 hasConcept C187869287 @default.
- W4387665956 hasConcept C2776412080 @default.
- W4387665956 hasConcept C2777180221 @default.
- W4387665956 hasConcept C2779159551 @default.
- W4387665956 hasConcept C2779901538 @default.
- W4387665956 hasConcept C2993967602 @default.
- W4387665956 hasConcept C54355233 @default.
- W4387665956 hasConcept C555293320 @default.
- W4387665956 hasConcept C60644358 @default.
- W4387665956 hasConcept C71924100 @default.
- W4387665956 hasConcept C86803240 @default.
- W4387665956 hasConceptScore W4387665956C104317684 @default.
- W4387665956 hasConceptScore W4387665956C106208931 @default.
- W4387665956 hasConceptScore W4387665956C118552586 @default.
- W4387665956 hasConceptScore W4387665956C134018914 @default.
- W4387665956 hasConceptScore W4387665956C135763542 @default.
- W4387665956 hasConceptScore W4387665956C153209595 @default.
- W4387665956 hasConceptScore W4387665956C15744967 @default.
- W4387665956 hasConceptScore W4387665956C169760540 @default.
- W4387665956 hasConceptScore W4387665956C169900460 @default.
- W4387665956 hasConceptScore W4387665956C187869287 @default.
- W4387665956 hasConceptScore W4387665956C2776412080 @default.
- W4387665956 hasConceptScore W4387665956C2777180221 @default.
- W4387665956 hasConceptScore W4387665956C2779159551 @default.
- W4387665956 hasConceptScore W4387665956C2779901538 @default.
- W4387665956 hasConceptScore W4387665956C2993967602 @default.
- W4387665956 hasConceptScore W4387665956C54355233 @default.
- W4387665956 hasConceptScore W4387665956C555293320 @default.
- W4387665956 hasConceptScore W4387665956C60644358 @default.
- W4387665956 hasConceptScore W4387665956C71924100 @default.
- W4387665956 hasConceptScore W4387665956C86803240 @default.
- W4387665956 hasLocation W43876659561 @default.
- W4387665956 hasOpenAccess W4387665956 @default.
- W4387665956 hasPrimaryLocation W43876659561 @default.
- W4387665956 hasRelatedWork W1893909712 @default.
- W4387665956 hasRelatedWork W2077427362 @default.
- W4387665956 hasRelatedWork W2131171966 @default.
- W4387665956 hasRelatedWork W2298807660 @default.
- W4387665956 hasRelatedWork W2324271132 @default.
- W4387665956 hasRelatedWork W2495861132 @default.
- W4387665956 hasRelatedWork W2506162896 @default.
- W4387665956 hasRelatedWork W2913571226 @default.
- W4387665956 hasRelatedWork W3140386247 @default.
- W4387665956 hasRelatedWork W4206746115 @default.
- W4387665956 isParatext "false" @default.
- W4387665956 isRetracted "false" @default.
- W4387665956 workType "article" @default.