FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387665984> ?p ?o ?g. }

• W4387665984 endingPage "10" @default.
• W4387665984 startingPage "1" @default.
• W4387665984 abstract "Objective. To investigate the targets and mechanisms of valsartan in the treatment of chronic renal failure based on network pharmacology and animal experiment validation. Methods. The objectives of using valsartan were predicted with the PubChem and SwissTargetPrediction databases. Relevant targets of chronic renal failure have been searched in various disease databases, with the common purposes of drugs and diseases extracted. Network analysis was carried out with the STRING database to construct a protein-protein interaction (PPI) network, as Cytoscape 3.9.1 software was used to analyze network topology of the key targets and establish the “valsartan-core target gene” network. Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed on core targets to explore their possible molecular mechanisms. The chronic renal failure mouse model was established by the plat method. Hematoxylin-eosin (H&E) and Masson staining observed morphological changes in renal problems of each group, as levels of serum Cre, BUN, T-SOD, and MDA in each group were detected by kit; real-time PCR was used to detect the relative expression of mRNA of TNF-αIL-1β, IL-6, and IL-10 in renal disease of mice in each group, with WB detect CALM, PKCα, and CaMKIV protein expression levels in renal disease from each group. Results. The network pharmacology approach identified 10 key targets for treatment of chronic renal failure with valsartan, including EGFR, PTGS2, PPARG, and ERBB2. KEGG enrichment analysis predicted that the drug exerted neuroactive ligand-receptor interaction, the calcium signaling pathway, the HIF-1 signaling pathway, the proteoglycans in cancer, PD-L1 expression, and the PD-1 checkpoint pathway in cancer. Results from animal experiments were compared to those of the model group, as renal function was significantly improved in the valsartan-dose group. The serum levels of Cre, BUN, and MDA and relative mRNA expression of TNF-α, IL-1β, and IL-6 decreased significantly, while serum T-SOD levels, relative mRNA expression of IL-10, and the protein expression level of CALM, PKCα, and CaMKIV increased significantly ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>P</mi> </math> < 0.05 and <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>P</mi> </math> < 0.001). Conclusion. Valsartan yields certain renal protection, which may improve chronic renal failure in mice through the calcium signaling pathway." @default.
• W4387665984 created "2023-10-17" @default.
• W4387665984 creator A5011856129 @default.
• W4387665984 creator A5021956079 @default.
• W4387665984 creator A5023837418 @default.
• W4387665984 creator A5027384206 @default.
• W4387665984 creator A5078210646 @default.
• W4387665984 date "2023-10-16" @default.
• W4387665984 modified "2023-10-17" @default.
• W4387665984 title "Exploration of the Mechanism of Valsartan Treatment in Chronic Renal Failure: Network Pharmacology and Experimental Validation" @default.
• W4387665984 cites W1979668300 @default.
• W4387665984 cites W1984393349 @default.
• W4387665984 cites W2009483350 @default.
• W4387665984 cites W2042985323 @default.
• W4387665984 cites W2044773944 @default.
• W4387665984 cites W2084226891 @default.
• W4387665984 cites W2098914497 @default.
• W4387665984 cites W2119248404 @default.
• W4387665984 cites W2143954917 @default.
• W4387665984 cites W2145632027 @default.
• W4387665984 cites W2149030597 @default.
• W4387665984 cites W2428722612 @default.
• W4387665984 cites W2504424910 @default.
• W4387665984 cites W2606731302 @default.
• W4387665984 cites W2615684303 @default.
• W4387665984 cites W2794605777 @default.
• W4387665984 cites W2794751688 @default.
• W4387665984 cites W2908210684 @default.
• W4387665984 cites W3161111692 @default.
• W4387665984 cites W3200530328 @default.
• W4387665984 cites W3204445870 @default.
• W4387665984 cites W4200045218 @default.
• W4387665984 cites W4309661436 @default.
• W4387665984 cites W4321495336 @default.
• W4387665984 doi "https://doi.org/10.1155/2023/4837743" @default.
• W4387665984 hasPublicationYear "2023" @default.
• W4387665984 type Work @default.
• W4387665984 citedByCount "0" @default.
• W4387665984 crossrefType "journal-article" @default.
• W4387665984 hasAuthorship W4387665984A5011856129 @default.
• W4387665984 hasAuthorship W4387665984A5021956079 @default.
• W4387665984 hasAuthorship W4387665984A5023837418 @default.
• W4387665984 hasAuthorship W4387665984A5027384206 @default.
• W4387665984 hasAuthorship W4387665984A5078210646 @default.
• W4387665984 hasBestOaLocation W43876659841 @default.
• W4387665984 hasConcept C104317684 @default.
• W4387665984 hasConcept C126322002 @default.
• W4387665984 hasConcept C150194340 @default.
• W4387665984 hasConcept C152724338 @default.
• W4387665984 hasConcept C158180186 @default.
• W4387665984 hasConcept C162317418 @default.
• W4387665984 hasConcept C2777387769 @default.
• W4387665984 hasConcept C55493867 @default.
• W4387665984 hasConcept C60644358 @default.
• W4387665984 hasConcept C70721500 @default.
• W4387665984 hasConcept C71924100 @default.
• W4387665984 hasConcept C84393581 @default.
• W4387665984 hasConcept C86803240 @default.
• W4387665984 hasConcept C98274493 @default.
• W4387665984 hasConceptScore W4387665984C104317684 @default.
• W4387665984 hasConceptScore W4387665984C126322002 @default.
• W4387665984 hasConceptScore W4387665984C150194340 @default.
• W4387665984 hasConceptScore W4387665984C152724338 @default.
• W4387665984 hasConceptScore W4387665984C158180186 @default.
• W4387665984 hasConceptScore W4387665984C162317418 @default.
• W4387665984 hasConceptScore W4387665984C2777387769 @default.
• W4387665984 hasConceptScore W4387665984C55493867 @default.
• W4387665984 hasConceptScore W4387665984C60644358 @default.
• W4387665984 hasConceptScore W4387665984C70721500 @default.
• W4387665984 hasConceptScore W4387665984C71924100 @default.
• W4387665984 hasConceptScore W4387665984C84393581 @default.
• W4387665984 hasConceptScore W4387665984C86803240 @default.
• W4387665984 hasConceptScore W4387665984C98274493 @default.
• W4387665984 hasFunder F4320334897 @default.
• W4387665984 hasLocation W43876659841 @default.
• W4387665984 hasOpenAccess W4387665984 @default.
• W4387665984 hasPrimaryLocation W43876659841 @default.
• W4387665984 hasRelatedWork W2104366126 @default.
• W4387665984 hasRelatedWork W2127553917 @default.
• W4387665984 hasRelatedWork W2169546341 @default.
• W4387665984 hasRelatedWork W2177317049 @default.
• W4387665984 hasRelatedWork W2235675062 @default.
• W4387665984 hasRelatedWork W2547231910 @default.
• W4387665984 hasRelatedWork W4205411122 @default.
• W4387665984 hasRelatedWork W4280643212 @default.
• W4387665984 hasRelatedWork W4293208996 @default.
• W4387665984 hasRelatedWork W4379536425 @default.
• W4387665984 hasVolume "2023" @default.
• W4387665984 isParatext "false" @default.
• W4387665984 isRetracted "false" @default.
• W4387665984 workType "article" @default.