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• W4387666023 abstract "First-degree relatives (FDR) of type 2 diabetes mellitus have increased risk of developing insulin resistance-related disorders including hyperuricemia. We investigated metabolic profile and serum uric acid (SUA) metabolism in response to high-fat diet among healthy male FDR in comparison to those without family history of diabetes. A total of 30 FDR and 30 non-FDR subjects completed a 5-days-hypercaloric diet with fat added to regular daily intake. Despite similar insulin response, FDR displayed different changes in SUA compared to non-FDR subjects (0.26 ± 0.83 mg/dL vs - 0.21 ± 0.78 mg/dL, p = 0.028). In subgroup analyses stratified by body mass index and waist circumference, significant different SUA changes between FDR and non-FDR subjects were only found in obese (0.48 ± 0.87 mg/dL vs - 0.70 ± 0.71 mg/dL, p = 0.001) and centrally obese (0.59 ± 0.83 mg/dL vs - 0.55 ± 0.82 mg/dL, p = 0.011) subgroups. In multivariate analysis, visceral adiposity seemed mediating the different response in SUA metabolism between FDR and non-FDR subjects induced by short-term obesogenic diet." @default.
• W4387666023 created "2023-10-17" @default.
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• W4387666023 date "2023-10-16" @default.
• W4387666023 modified "2023-10-18" @default.
• W4387666023 title "The role of high fat diet on serum uric acid level among healthy male first degree relatives of type 2 diabetes mellitus" @default.
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• W4387666023 doi "https://doi.org/10.1038/s41598-023-44843-8" @default.
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• W4387666023 hasPublicationYear "2023" @default.
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