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- W4387666109 abstract "Abstract Background IgA nephropathy (IgAN) is the most frequent recurrent disease in kidney transplant recipients (KTx) and its recurrence contributes to reducing graft survival. Several variables at the time of recurrence have been associated with a higher risk of graft loss. The presence of clinical or subclinical inflammation has been associated with a higher risk of kidney graft loss, but it is not precisely known how it influences the outcome of patients with recurrent IgAN. Methods We performed a multicenter retrospective study including KTx with biopsy-proven recurrence of IgAN in which Banff and Oxford classification scores were available. ‘Tubulo-interstitial inflammation’ (TII) was defined when ‘t’ or ‘i’ were ≥ 2. The main endpoint was progression to CKD stage 5 or to death censored-graft loss (CKD5/DCGL). Results 119 KTx with IgA nephropathy recurrence were included and 23 of them showed TII. Median follow-up was 102.9 months and 39 (32.8%) patients reached CKD5/DCGL. TII related to a higher risk of CKD5/DCGL (3 years 18.0% vs. 45.3%, log-rank 7.588, P = 0.006). After multivariate analysis, TII remained related to the risk of CKD5/DCGL (HR 2.344, 95%CI 1.119–4.910, P = 0.024) independently of other histologic and clinical variables. Conclusions In KTx with IgAN recurrence, TII contributes to increasing the risk of CKD5/DCGL independently of previously well-known variables. We suggest adding TII along with the Oxford classification to the clinical variables to identify recurrent IgAN patients at increased risk of graft loss who might benefit from intensified immunosuppression or specific IgAN therapies." @default.
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- W4387666109 date "2023-10-16" @default.
- W4387666109 modified "2023-10-18" @default.
- W4387666109 title "Tubulo-interstitial inflammation increases the risk of graft loss after the recurrence of IgA nephropathy" @default.
- W4387666109 doi "https://doi.org/10.1093/ckj/sfad259" @default.
- W4387666109 hasPublicationYear "2023" @default.
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