FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387666345> ?p ?o ?g. }

• W4387666345 abstract "Background Irreversible electroporation is a novel approach for treating locally advanced pancreatic adenocarcinoma. However, this ablative technique is not without risk and has the potential to precipitate adverse events. The aim of this study was to delineate risk factors that increase this risk, as well as to elucidate the risk profile associated with irreversible electroporation in the setting of locally advanced pancreatic adenocarcinoma. Methods A review of our prospective multi-institutional database from December 2015 to March 2022 of patients with locally advanced pancreatic adenocarcinoma who underwent irreversible electroporation was analyzed for adverse events. These were then compared with a control population of patients undergoing pancreatectomy for adenocarcinoma. Results Adverse events occurred in 51 patients of the 201 patients treated with irreversible electroporation compared with 78 of the 200 patients treated with pancreatectomy. The irreversible electroporation group had a significantly greater incidence of postoperative ascites in stage 3C patients. The most common complications in the irreversible electroporation group were infectious (n = 13), gastrointestinal bleed (n = 11), and ascites (n = 7). Multivariate analysis demonstrated increased risk of severe (grade ≥3) adverse events in the irreversible electroporation cohort who received high dose, neoadjuvant radiation (hazard ratio, 2.4; 95% confidence interval, 1.4–5.4), irreversible electroporation electrodes bracketing the superior mesenteric artery, superior mesenteric vein, and portal venous vein (hazard ratio, 1.9; 95% confidence interval, 1.3–3.4), and who had a bile duct stent in place for >6 months (hazard ratio, 1.7; 95% confidence interval, 1.2–5.6). There were similar rates of 90-day mortality in both groups, irreversible electroporation 2.4% vs pancreatectomy 2.8%. Conclusion This study revealed a 25% rate of adverse events associated with irreversible electroporation in locally advanced pancreatic adenocarcinoma, which was significantly less (P = .004) than the 39% rate of adverse events associated with pancreatectomy in early-stage disease. Certain unique adverse events in the irreversible electroporation group have been established and should be understood in the care of these patients." @default.
• W4387666345 created "2023-10-17" @default.
• W4387666345 creator A5011696445 @default.
• W4387666345 creator A5067294489 @default.
• W4387666345 creator A5069026924 @default.
• W4387666345 creator A5071286571 @default.
• W4387666345 creator A5071405425 @default.
• W4387666345 creator A5087832965 @default.
• W4387666345 date "2023-10-01" @default.
• W4387666345 modified "2023-10-17" @default.
• W4387666345 title "Multi-institutional review of adverse events associated with irreversible electroporation in the treatment of locally advanced pancreatic cancer" @default.
• W4387666345 cites W1894182878 @default.
• W4387666345 cites W1986190753 @default.
• W4387666345 cites W2041119827 @default.
• W4387666345 cites W2043535841 @default.
• W4387666345 cites W2078695541 @default.
• W4387666345 cites W2103711657 @default.
• W4387666345 cites W2105167040 @default.
• W4387666345 cites W2122041824 @default.
• W4387666345 cites W2144173184 @default.
• W4387666345 cites W2151253787 @default.
• W4387666345 cites W2172089182 @default.
• W4387666345 cites W2345822778 @default.
• W4387666345 cites W2346921980 @default.
• W4387666345 cites W2606158727 @default.
• W4387666345 cites W2772770935 @default.
• W4387666345 cites W2903623792 @default.
• W4387666345 cites W2911188335 @default.
• W4387666345 cites W2913194404 @default.
• W4387666345 cites W2929408960 @default.
• W4387666345 cites W2981512950 @default.
• W4387666345 cites W3086844699 @default.
• W4387666345 cites W3130863604 @default.
• W4387666345 cites W3165133969 @default.
• W4387666345 cites W3165297240 @default.
• W4387666345 cites W3166511756 @default.
• W4387666345 cites W4206491159 @default.
• W4387666345 cites W4214901113 @default.
• W4387666345 cites W4253769310 @default.
• W4387666345 cites W4294068510 @default.
• W4387666345 cites W4308768095 @default.
• W4387666345 cites W4318018999 @default.
• W4387666345 cites W4376132558 @default.
• W4387666345 doi "https://doi.org/10.1016/j.surg.2023.08.042" @default.
• W4387666345 hasPublicationYear "2023" @default.
• W4387666345 type Work @default.
• W4387666345 citedByCount "0" @default.
• W4387666345 crossrefType "journal-article" @default.
• W4387666345 hasAuthorship W4387666345A5011696445 @default.
• W4387666345 hasAuthorship W4387666345A5067294489 @default.
• W4387666345 hasAuthorship W4387666345A5069026924 @default.
• W4387666345 hasAuthorship W4387666345A5071286571 @default.
• W4387666345 hasAuthorship W4387666345A5071405425 @default.
• W4387666345 hasAuthorship W4387666345A5087832965 @default.
• W4387666345 hasConcept C104317684 @default.
• W4387666345 hasConcept C121608353 @default.
• W4387666345 hasConcept C126322002 @default.
• W4387666345 hasConcept C141071460 @default.
• W4387666345 hasConcept C185592680 @default.
• W4387666345 hasConcept C186852380 @default.
• W4387666345 hasConcept C197934379 @default.
• W4387666345 hasConcept C207103383 @default.
• W4387666345 hasConcept C2778716261 @default.
• W4387666345 hasConcept C2781182431 @default.
• W4387666345 hasConcept C44249647 @default.
• W4387666345 hasConcept C55493867 @default.
• W4387666345 hasConcept C71924100 @default.
• W4387666345 hasConcept C90924648 @default.
• W4387666345 hasConceptScore W4387666345C104317684 @default.
• W4387666345 hasConceptScore W4387666345C121608353 @default.
• W4387666345 hasConceptScore W4387666345C126322002 @default.
• W4387666345 hasConceptScore W4387666345C141071460 @default.
• W4387666345 hasConceptScore W4387666345C185592680 @default.
• W4387666345 hasConceptScore W4387666345C186852380 @default.
• W4387666345 hasConceptScore W4387666345C197934379 @default.
• W4387666345 hasConceptScore W4387666345C207103383 @default.
• W4387666345 hasConceptScore W4387666345C2778716261 @default.
• W4387666345 hasConceptScore W4387666345C2781182431 @default.
• W4387666345 hasConceptScore W4387666345C44249647 @default.
• W4387666345 hasConceptScore W4387666345C55493867 @default.
• W4387666345 hasConceptScore W4387666345C71924100 @default.
• W4387666345 hasConceptScore W4387666345C90924648 @default.
• W4387666345 hasLocation W43876663451 @default.
• W4387666345 hasOpenAccess W4387666345 @default.
• W4387666345 hasPrimaryLocation W43876663451 @default.
• W4387666345 hasRelatedWork W2090763189 @default.
• W4387666345 hasRelatedWork W2154948599 @default.
• W4387666345 hasRelatedWork W2483183840 @default.
• W4387666345 hasRelatedWork W2516062397 @default.
• W4387666345 hasRelatedWork W2792916732 @default.
• W4387666345 hasRelatedWork W2793335702 @default.
• W4387666345 hasRelatedWork W2913113213 @default.
• W4387666345 hasRelatedWork W3114266572 @default.
• W4387666345 hasRelatedWork W4210646467 @default.
• W4387666345 hasRelatedWork W4254083861 @default.
• W4387666345 isParatext "false" @default.
• W4387666345 isRetracted "false" @default.
• W4387666345 workType "article" @default.