FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387668635> ?p ?o ?g. }

• W4387668635 endingPage "2065" @default.
• W4387668635 startingPage "2065" @default.
• W4387668635 abstract "Background: Various pharmacokinetic/pharmacodynamic (PK/PD) models have been developed to accurately dose propofol administration during total intravenous anesthesia with target-controlled infusion (TIVA-TCI). We aim to clinically compare the performance of the Schnider model and the new and general-purpose Eleveld PK/PD model during TIVA-TCI. Methods: We conducted a prospective observational study at a single center, enrolling 78 female patients, including 37 adults (aged < 65 years) and 41 elderly patients (aged ≥ 65 years). These patients underwent breast surgery with propofol-remifentanil TIVA-TCI guided by the bispectral index (BIS) for depth of anesthesia monitoring (target value 40–60) and the surgical plethysmographic index (SPI) for antinociception monitoring (target value 20–50) without neuromuscular blockade. The concentration at the effect site of propofol (CeP) at loss of responsiveness (LoR) during anesthesia maintenance (MA) and at return of responsiveness (RoR), the duration of surgery and anesthesia (min), the time to RoR (min), the propofol total dose (mg), the deepening of anesthesia events (DAEs), burst suppression events (BSEs), light anesthesia events (LAEs) and unwanted spontaneous responsiveness events (USREs) were considered to compare the two PK/PD models. Results: Patients undergoing BIS-SPI-guided TIVA-TCI with the Eleveld PK/PD model showed a lower CeP at LoR (1.7 (1.36–2.25) vs. 3.60 (3.00–4.18) μg/mL, p < 0.001), higher CePMA (2.80 (2.55–3.40) vs. 2.30 (1.80–2.50) μg/mL, p < 0.001) and at RoR (1.48 (1.08–1.80) vs. 0.64 (0.55–0.81) μg/mL, p < 0.001) than with the Schnider PK/PD model. Anesthetic hysteresis was observed only in the Schnider PK/PD model group (p < 0.001). DAEs (69.2% vs. 30.8%, p = 0.001) and BSEs (28.2% vs. 5.1%, p = 0.013) were more frequent with the Eleveld PK/PD model than with the Schnider PK/PD model in the general patient population. DAEs (63.2% vs. 27.3%, p = 0.030) and BSEs (31.6% vs. 4.5%, p = 0.036) were more frequent with the Eleveld PK/PD model than with the Schnider PK/PD model in the elderly. Conclusions: The Schnider and Eleveld PK/PD models impact CePs differently. A greater incidence of DAEs and BSEs in the elderly suggests more attention is necessary in this group of patients undergoing BIS-SPI-guided TIVA-TCI with the Eleveld PK/PD than with the Schnider model." @default.
• W4387668635 created "2023-10-17" @default.
• W4387668635 creator A5005780350 @default.
• W4387668635 creator A5019181108 @default.
• W4387668635 creator A5019693447 @default.
• W4387668635 creator A5035004256 @default.
• W4387668635 creator A5081063035 @default.
• W4387668635 creator A5087367222 @default.
• W4387668635 date "2023-10-16" @default.
• W4387668635 modified "2023-10-17" @default.
• W4387668635 title "Schnider and Eleveld Models for Propofol Target-Controlled Infusion Anesthesia: A Clinical Comparison" @default.
• W4387668635 cites W1537972189 @default.
• W4387668635 cites W1538826226 @default.
• W4387668635 cites W1965614042 @default.
• W4387668635 cites W1973723804 @default.
• W4387668635 cites W1984595009 @default.
• W4387668635 cites W1993838145 @default.
• W4387668635 cites W2002183692 @default.
• W4387668635 cites W2024687868 @default.
• W4387668635 cites W2049408930 @default.
• W4387668635 cites W2056113812 @default.
• W4387668635 cites W2058138388 @default.
• W4387668635 cites W2067957582 @default.
• W4387668635 cites W2115473091 @default.
• W4387668635 cites W2121819108 @default.
• W4387668635 cites W2122171313 @default.
• W4387668635 cites W2134546466 @default.
• W4387668635 cites W2135893210 @default.
• W4387668635 cites W2137546126 @default.
• W4387668635 cites W2138815770 @default.
• W4387668635 cites W2205930502 @default.
• W4387668635 cites W2262615478 @default.
• W4387668635 cites W2488700677 @default.
• W4387668635 cites W2517498544 @default.
• W4387668635 cites W2610345163 @default.
• W4387668635 cites W2753762436 @default.
• W4387668635 cites W2779946977 @default.
• W4387668635 cites W2791801802 @default.
• W4387668635 cites W2954625661 @default.
• W4387668635 cites W3004803516 @default.
• W4387668635 cites W3015078307 @default.
• W4387668635 cites W3092722417 @default.
• W4387668635 cites W3093005457 @default.
• W4387668635 cites W3112253345 @default.
• W4387668635 cites W3114881781 @default.
• W4387668635 cites W3197314412 @default.
• W4387668635 cites W4225123704 @default.
• W4387668635 cites W4237872303 @default.
• W4387668635 cites W4281643340 @default.
• W4387668635 cites W4317708547 @default.
• W4387668635 doi "https://doi.org/10.3390/life13102065" @default.
• W4387668635 hasPublicationYear "2023" @default.
• W4387668635 type Work @default.
• W4387668635 citedByCount "0" @default.
• W4387668635 crossrefType "journal-article" @default.
• W4387668635 hasAuthorship W4387668635A5005780350 @default.
• W4387668635 hasAuthorship W4387668635A5019181108 @default.
• W4387668635 hasAuthorship W4387668635A5019693447 @default.
• W4387668635 hasAuthorship W4387668635A5035004256 @default.
• W4387668635 hasAuthorship W4387668635A5081063035 @default.
• W4387668635 hasAuthorship W4387668635A5087367222 @default.
• W4387668635 hasBestOaLocation W43876686351 @default.
• W4387668635 hasConcept C111113717 @default.
• W4387668635 hasConcept C112705442 @default.
• W4387668635 hasConcept C2776277131 @default.
• W4387668635 hasConcept C2776442465 @default.
• W4387668635 hasConcept C2778891214 @default.
• W4387668635 hasConcept C2781097354 @default.
• W4387668635 hasConcept C42219234 @default.
• W4387668635 hasConcept C71924100 @default.
• W4387668635 hasConcept C98274493 @default.
• W4387668635 hasConceptScore W4387668635C111113717 @default.
• W4387668635 hasConceptScore W4387668635C112705442 @default.
• W4387668635 hasConceptScore W4387668635C2776277131 @default.
• W4387668635 hasConceptScore W4387668635C2776442465 @default.
• W4387668635 hasConceptScore W4387668635C2778891214 @default.
• W4387668635 hasConceptScore W4387668635C2781097354 @default.
• W4387668635 hasConceptScore W4387668635C42219234 @default.
• W4387668635 hasConceptScore W4387668635C71924100 @default.
• W4387668635 hasConceptScore W4387668635C98274493 @default.
• W4387668635 hasIssue "10" @default.
• W4387668635 hasLocation W43876686351 @default.
• W4387668635 hasOpenAccess W4387668635 @default.
• W4387668635 hasPrimaryLocation W43876686351 @default.
• W4387668635 hasRelatedWork W1974348264 @default.
• W4387668635 hasRelatedWork W2003339380 @default.
• W4387668635 hasRelatedWork W2068841520 @default.
• W4387668635 hasRelatedWork W2261570036 @default.
• W4387668635 hasRelatedWork W2350247811 @default.
• W4387668635 hasRelatedWork W2359589008 @default.
• W4387668635 hasRelatedWork W2369704159 @default.
• W4387668635 hasRelatedWork W2370068612 @default.
• W4387668635 hasRelatedWork W2388342822 @default.
• W4387668635 hasRelatedWork W2466096929 @default.
• W4387668635 hasVolume "13" @default.
• W4387668635 isParatext "false" @default.
• W4387668635 isRetracted "false" @default.
• W4387668635 workType "article" @default.