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- W4387669404 abstract "This chapter firstly did the work skillfully and locally by optimizing the structures of RNA-dependent RNA polymerase (RdRp) in complex with its cofactors, i.e., NSP7 and NSP8 (6M71.pdb6M71.pdb and 7BTF.pdb), respectively, from COVID-19 virus; then some new structural bioinformatics from the structures optimized for developing therapies of the currently fatal COVID-19 virus are reported. Currently, lots of researchers are using optimization to screen, dock, and design new therapies for COVID-19 but it is not used professionally. The hybrid strategy of mathematical optimization’s neighboring different (local search) algorithms is used professionally in this chapter. For RdRp, we found two new salt bridges: A:GLU729-A:HIS725 and A:GLU610-A:HIS752. The polar contacts A:ASP274-B:ARG111 and A:ARG331-B:ASP112 and the hydrogen bond A:VAL330.N-B:VAL115.O (with 51.98% occupancy rate during 10 $$upmu $$ s of molecular dynamics simulation), etc. strongly make the in complex between RdRp and its cofactor Nsp8." @default.
- W4387669404 created "2023-10-17" @default.
- W4387669404 creator A5073312483 @default.
- W4387669404 date "2023-01-01" @default.
- W4387669404 modified "2023-10-17" @default.
- W4387669404 title "RNA-Dependent RNA Polymerase (RdRp)" @default.
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- W4387669404 doi "https://doi.org/10.1007/978-3-031-36773-1_3" @default.
- W4387669404 hasPublicationYear "2023" @default.
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