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- W4387673023 abstract "High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a key mediator of chromosome missegregation, may have significant clinical utility in HGSOC. However, the prevalence of CA in HGSOC, its relationship to genomic biomarkers of CIN and its potential impact on therapeutic response have not been defined. Using high-throughput multi-regional microscopy on 287 clinical HGSOC tissues and 73 cell lines models, here we show that CA through centriole overduplication is a highly recurrent and heterogeneous feature of HGSOC and strongly associated with CIN and genome subclonality. Cell-based studies showed that high-prevalence CA is phenocopied in ovarian cancer cell lines, and that high CA is associated with increased multi-treatment resistance; most notably to paclitaxel, the commonest treatment used in HGSOC. CA in HGSOC may therefore present a potential driver of tumour evolution and a powerful biomarker for response to standard-of-care treatment." @default.
- W4387673023 created "2023-10-17" @default.
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- W4387673023 date "2023-10-16" @default.
- W4387673023 modified "2023-10-18" @default.
- W4387673023 title "Molecular landscape and functional characterization of centrosome amplification in ovarian cancer" @default.
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- W4387673023 doi "https://doi.org/10.1038/s41467-023-41840-3" @default.
- W4387673023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37845213" @default.
- W4387673023 hasPublicationYear "2023" @default.
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