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- W4387674788 abstract "A targeted extraction, enrichment and separation method for polyunsaturated amides from Zanthoxylum bungeanum was established. Three main polyunsaturated amide monomers with high purity were isolated at the same time: hydroxyl-α-sanshool (HAS), hydroxyl-β-sanshool (HBS), hydroxyl-ε-sanshool (HES). This efficient method combined high-pressure supercritical fluid extraction (HPSFE) and industrial chromatography purification technology. By studying the extraction kinetics of target polyunsaturated amide monomers, the operation parameters of HPSFE were optimized. Meanwhile, a HPLC method for simultaneous determination of three polyunsaturated amide monomers was established in order to optimize process. Under the optimal conditions of high-pressure extraction, the extraction equilibration time was 45 min, the content of total polyunsaturated amides reached 27.53%, and the yield was 2.89%. At last, three high-purity polyunsaturated amide monomers were obtained, namely HES (95.16%), HAS (98.43%), and HBS (98.72%). The in vitro cell assay showed that IC50 values of HES, HAS and HBS on the inflammatory factor NO were 14.5, 14.7 and 13.4 μg/mL, respectively. IC50 values on TNF-α and IL-6 were 21.2, 29.4, 23.9 μg/mL and 8.2, 7.0, 8.7 μg/mL, similarly. The Pharmacological studies showed that PA have obvious anti-inflammatory activity as one of the main effective components of ZB." @default.
- W4387674788 created "2023-10-17" @default.
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- W4387674788 date "2023-10-01" @default.
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- W4387674788 title "Efficient Isolation of Polyunsaturated Amides from Zanthoxylum bungeanum and Assessment of their Anti-inflammatory Potential" @default.
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- W4387674788 doi "https://doi.org/10.1016/j.seppur.2023.125298" @default.
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