FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387674842> ?p ?o ?g. }

• W4387674842 abstract "The serotonin transporter (5-HTT, SERT, SLC6A4) modulates the activity of serotonin via sodium-dependent reuptake. Given the established importance of serotonin in the control of pain, 5-HTT has received much interest in studies of pain states and as a pharmacological target for serotonin reuptake inhibitors (SRIs). Animal models expressing varying levels of 5-HTT activity show marked differences in pain behaviors and analgesic responses, as well as many serotonin-related physiological effects. In humans, functional nucleotide variations in the SLC6A4 gene, which encodes the serotonin transporter 5-HTT, are associated with certain pathologic pain conditions and differences in responses to pharmacological therapy. These findings collectively reflect the importance of 5-HTT in the intricate physiology and management of pain, as well as the scientific and clinical challenges that need to be considered for optimization of 5-HTT related analgesic therapies. PERSPECTIVES The serotonin transporter 5-HTT/SCL6A4 is sensitive to pharmacological serotonin re-uptake inhibitors. Experimental studies on the physiological functions of serotonin, as well as genetic mouse models and clinical phenotype/genotype correlations of nucleotide variation in the human 5-HTT/SCL6A4 gene provide new insights for the use of SRIs in chronic pain management." @default.
• W4387674842 created "2023-10-17" @default.
• W4387674842 creator A5008755139 @default.
• W4387674842 creator A5014315694 @default.
• W4387674842 creator A5070698314 @default.
• W4387674842 date "2023-10-01" @default.
• W4387674842 modified "2023-10-18" @default.
• W4387674842 title "Serotonin transporter (5-HTT, SERT, SLC6A4) and sodium-dependent reuptake inhibitors (SRIs) as modulators of pain behaviors and analgesic responses" @default.
• W4387674842 cites W1491233801 @default.
• W4387674842 cites W1499975795 @default.
• W4387674842 cites W179873229 @default.
• W4387674842 cites W1814488946 @default.
• W4387674842 cites W1902452403 @default.
• W4387674842 cites W1926851645 @default.
• W4387674842 cites W1964497912 @default.
• W4387674842 cites W1970208738 @default.
• W4387674842 cites W1974831280 @default.
• W4387674842 cites W1977949510 @default.
• W4387674842 cites W1982188027 @default.
• W4387674842 cites W1984455353 @default.
• W4387674842 cites W1988036797 @default.
• W4387674842 cites W1989799718 @default.
• W4387674842 cites W1991731575 @default.
• W4387674842 cites W1996889745 @default.
• W4387674842 cites W2004435166 @default.
• W4387674842 cites W2005534453 @default.
• W4387674842 cites W2021701145 @default.
• W4387674842 cites W2023867415 @default.
• W4387674842 cites W2025880338 @default.
• W4387674842 cites W2030081504 @default.
• W4387674842 cites W2034380066 @default.
• W4387674842 cites W2034864352 @default.
• W4387674842 cites W2036062643 @default.
• W4387674842 cites W2036911239 @default.
• W4387674842 cites W2041383977 @default.
• W4387674842 cites W2048175288 @default.
• W4387674842 cites W2049044379 @default.
• W4387674842 cites W2050340080 @default.
• W4387674842 cites W2057793522 @default.
• W4387674842 cites W2059082210 @default.
• W4387674842 cites W2069918422 @default.
• W4387674842 cites W2070861496 @default.
• W4387674842 cites W2071405464 @default.
• W4387674842 cites W2073006000 @default.
• W4387674842 cites W2075468419 @default.
• W4387674842 cites W2075659401 @default.
• W4387674842 cites W2077254617 @default.
• W4387674842 cites W2078026557 @default.
• W4387674842 cites W2078384718 @default.
• W4387674842 cites W2082179080 @default.
• W4387674842 cites W2086751952 @default.
• W4387674842 cites W2091096177 @default.
• W4387674842 cites W2099809369 @default.
• W4387674842 cites W2106095564 @default.
• W4387674842 cites W2106966110 @default.
• W4387674842 cites W2110067113 @default.
• W4387674842 cites W2112873785 @default.
• W4387674842 cites W2112910543 @default.
• W4387674842 cites W2114757751 @default.
• W4387674842 cites W2119336416 @default.
• W4387674842 cites W2120501716 @default.
• W4387674842 cites W2124984580 @default.
• W4387674842 cites W2125867146 @default.
• W4387674842 cites W2126307255 @default.
• W4387674842 cites W2132167094 @default.
• W4387674842 cites W2135190897 @default.
• W4387674842 cites W2138347065 @default.
• W4387674842 cites W2145728616 @default.
• W4387674842 cites W2148694444 @default.
• W4387674842 cites W2149823098 @default.
• W4387674842 cites W2154301402 @default.
• W4387674842 cites W2156743186 @default.
• W4387674842 cites W2156791952 @default.
• W4387674842 cites W2157103853 @default.
• W4387674842 cites W2158533153 @default.
• W4387674842 cites W2159484313 @default.
• W4387674842 cites W2165348247 @default.
• W4387674842 cites W2168557513 @default.
• W4387674842 cites W2171751400 @default.
• W4387674842 cites W2172156978 @default.
• W4387674842 cites W2331665880 @default.
• W4387674842 cites W2336317475 @default.
• W4387674842 cites W2344678614 @default.
• W4387674842 cites W2414740018 @default.
• W4387674842 cites W2522799228 @default.
• W4387674842 cites W2592646799 @default.
• W4387674842 cites W2594459623 @default.
• W4387674842 cites W2601063088 @default.
• W4387674842 cites W2612658271 @default.
• W4387674842 cites W2620912728 @default.
• W4387674842 cites W2765964288 @default.
• W4387674842 cites W2801928822 @default.
• W4387674842 cites W2884055058 @default.
• W4387674842 cites W2887089493 @default.
• W4387674842 cites W2891660975 @default.
• W4387674842 cites W2898451802 @default.
• W4387674842 cites W2900255713 @default.
• W4387674842 cites W2901968415 @default.
• W4387674842 cites W2918305300 @default.
• W4387674842 cites W2937369405 @default.

• next