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- W4387675480 abstract "Alzheimer’s disease (AD) research has entered a new era with the recent positive phase 3 clinical trials of the anti-Aβ antibodies lecanemab and donanemab. Why did it take 30 years to achieve these successes? Developing potent therapies for reducing fibrillar amyloid was key, as was selection of patients at relatively early stages of disease. Biomarkers of the target pathologies, including amyloid and tau PET, and insights from past trials were also critical to the recent successes. Moving forward, the challenge will be to develop more efficacious therapies with greater efficiency. Novel trial designs, including combination therapies and umbrella and basket protocols, will accelerate clinical development. Better diversity and inclusivity of trial participants are needed, and blood-based biomarkers may help to improve access for medically underserved groups. Incentivizing innovation in both academia and industry through public-private partnerships, collaborative mechanisms, and the creation of new career paths will be critical to build momentum in these exciting times." @default.
- W4387675480 created "2023-10-17" @default.
- W4387675480 creator A5001795846 @default.
- W4387675480 creator A5019555711 @default.
- W4387675480 date "2023-10-01" @default.
- W4387675480 modified "2023-10-17" @default.
- W4387675480 title "Accelerating Alzheimer’s therapeutic development: The past and future of clinical trials" @default.
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- W4387675480 doi "https://doi.org/10.1016/j.cell.2023.09.023" @default.
- W4387675480 hasPublicationYear "2023" @default.
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