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- W4387675765 endingPage "115885" @default.
- W4387675765 startingPage "115885" @default.
- W4387675765 abstract "The opportunistic apicomplexan parasite Toxoplasma gondii is the etiologic agent for toxoplasmosis, which can infect a widespread range of hosts, particularly humans and warm-blooded animals. The present chemotherapy to treat or prevent toxoplasmosis is deficient and is based on diverse drugs such as atovaquone, trimethoprim, spiramycine, which are effective in acute toxoplasmosis. Therefore, a safe chemotherapy is required for toxoplasmosis considering that its responsible agent, T. gondii, provokes severe illness and death in pregnant women and immunodeficient patients. A certain disadvantage of the available treatments is the lack of effectiveness against the tissue cyst of the parasite. A safe chemotherapy to combat toxoplasmosis should be based on the metabolic differences between the parasite and the mammalian host. This article covers different relevant molecular targets to combat this disease including the isoprenoid pathway (farnesyl diphosphate synthase, squalene synthase), dihydrofolate reductase, calcium-dependent protein kinases, histone deacetylase, mitochondrial electron transport chain, etc." @default.
- W4387675765 created "2023-10-17" @default.
- W4387675765 creator A5060367228 @default.
- W4387675765 creator A5080749101 @default.
- W4387675765 date "2023-10-01" @default.
- W4387675765 modified "2023-10-17" @default.
- W4387675765 title "An updated review of chemical compounds with anti-Toxoplasma gondii activity" @default.
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