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- W4387680087 abstract "The hemostasis system was studied in 35 cancer patients with comorbid terminal chronic renal failure (tCFR) before and after program hemodialysis (HD) at different stages of treatment. All patients underwent bicarbonate HD using equipment 4008 S (Fresenius, Germany). Appropriate anticoagulation was performed according to the following scheme: at the beginning of the procedure, 1000-3000 units of sodium heparin were injected into the extracorporeal system; further in the process of extracorporeal hemocorrection operation the dose of sodium heparin was from 5 to 15 U/kg of body weight per hour. Hypercoagulability with signs of activation of intravascular blood coagulation, combined with impaired synthesis of individual coagulation factors, occurred in cancer patients with tCFR before the start of renal replacement therapy (RRT). All patients underwent HD procedure 3 times a week. After completion of the programmed HD procedure, multidirectional changes in the hemostasis system were observed. On the one hand, significant hypercoagulability with signs of intravascular coagulation activation remained, which increases the risk of thrombotic complications, on the other hand — prolongation of activated partial thromboplastin time (APTT), decreased activity of prothrombin complex factors and platelet aggregation ability increased the risk of hemorrhagic complications, which dictates the need for a cautious, balanced approach to the prescription of anticoagulants. According to Doppler ultrasonography (DU) in duplex mode of paired vessels (arteries or veins), no signs of thrombosis were detected. The mean hemoglobin level and platelet count before and after the programmed HD procedure did not differ. The use of programmed HD in cancer patients with tCFR, taking into account blood parameters, allows for adequate antitumor treatment, improves the quality and prognosis of life of cancer patients." @default.
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- W4387680087 date "2023-01-01" @default.
- W4387680087 modified "2023-10-17" @default.
- W4387680087 title "Features of the hemostasis system in cancer patients on program hemodialysis" @default.
- W4387680087 doi "https://doi.org/10.53652/2782-1730-2023-4-3-25-30" @default.
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