Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387680979> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4387680979 endingPage "177" @default.
- W4387680979 startingPage "177" @default.
- W4387680979 abstract "Background: Autophagy is a catabolic process whereby organelles and long-lived proteins are recycled through lysosomes to maintain cellular homeostasis. This process is being widely studied using culture techniques and animal models; however, cervicovaginal smears have not been used to detect autophagy. Aims: Our study aims to detect and evaluate autophagy in normal, malignant, infectious, and atypical cells in cervicovaginal smears by using cytological and immunocytochemical methods. Materials and Methods: Papanicolaou-stained 200 cervicovaginal smears were examined and 55 of 200 (27.5%) smears containing negative for intraepithelial lesion or malignancy (NILM) with identifiable infections and/or reactive/reparative changes (INF); briefly, NILM-INF (n = 31, 56.4%), atypical (n = 4, 7.3%), and malignant cells (n = 20, 36.3%) were evaluated as a study group. One hundred forty-five of 200 (72.5%) normal smears were accepted as the NILM without any identifiable infections (control group). The autophagy marker protein Microtubule-associated protein 1 light chain 3 A (MAP1LC3A) was used for immunocytochemical examination. Results: The staining intensity of the MAP1LC3A protein and autophagy positivity were lower in the malignant cells; however, they were higher in the NILM-INF and atypical cells. A statistically significant correlation between the malignant and normal cells was obtained for the autophagy positivity (P = 0.012). In view of the staining intensity of MAP1LC3A protein by the H-score method, a significant correlation was found between the NILM-INF and the normal cells (P = 0.015). Conclusions: Autophagy was detected in various cervicovaginal smears for the first time in this study. Our findings indicate that an autophagy process is essential in infectious cells as well as in the transformation of atypical cells into malignant cells in carcinogenesis." @default.
- W4387680979 created "2023-10-17" @default.
- W4387680979 creator A5015712170 @default.
- W4387680979 creator A5084042075 @default.
- W4387680979 creator A5089893100 @default.
- W4387680979 date "2023-01-01" @default.
- W4387680979 modified "2023-10-18" @default.
- W4387680979 title "Determination of autophagy in human cervicovaginal smears by cytological and İmmunocytochemical methods" @default.
- W4387680979 doi "https://doi.org/10.4103/joc.joc_130_22" @default.
- W4387680979 hasPublicationYear "2023" @default.
- W4387680979 type Work @default.
- W4387680979 citedByCount "0" @default.
- W4387680979 crossrefType "journal-article" @default.
- W4387680979 hasAuthorship W4387680979A5015712170 @default.
- W4387680979 hasAuthorship W4387680979A5084042075 @default.
- W4387680979 hasAuthorship W4387680979A5089893100 @default.
- W4387680979 hasBestOaLocation W43876809791 @default.
- W4387680979 hasConcept C121608353 @default.
- W4387680979 hasConcept C126322002 @default.
- W4387680979 hasConcept C142724271 @default.
- W4387680979 hasConcept C190283241 @default.
- W4387680979 hasConcept C203522944 @default.
- W4387680979 hasConcept C2778220009 @default.
- W4387680979 hasConcept C2779399171 @default.
- W4387680979 hasConcept C2908603675 @default.
- W4387680979 hasConcept C55493867 @default.
- W4387680979 hasConcept C65051434 @default.
- W4387680979 hasConcept C71924100 @default.
- W4387680979 hasConcept C74864618 @default.
- W4387680979 hasConcept C86803240 @default.
- W4387680979 hasConceptScore W4387680979C121608353 @default.
- W4387680979 hasConceptScore W4387680979C126322002 @default.
- W4387680979 hasConceptScore W4387680979C142724271 @default.
- W4387680979 hasConceptScore W4387680979C190283241 @default.
- W4387680979 hasConceptScore W4387680979C203522944 @default.
- W4387680979 hasConceptScore W4387680979C2778220009 @default.
- W4387680979 hasConceptScore W4387680979C2779399171 @default.
- W4387680979 hasConceptScore W4387680979C2908603675 @default.
- W4387680979 hasConceptScore W4387680979C55493867 @default.
- W4387680979 hasConceptScore W4387680979C65051434 @default.
- W4387680979 hasConceptScore W4387680979C71924100 @default.
- W4387680979 hasConceptScore W4387680979C74864618 @default.
- W4387680979 hasConceptScore W4387680979C86803240 @default.
- W4387680979 hasIssue "4" @default.
- W4387680979 hasLocation W43876809791 @default.
- W4387680979 hasOpenAccess W4387680979 @default.
- W4387680979 hasPrimaryLocation W43876809791 @default.
- W4387680979 hasRelatedWork W1978654011 @default.
- W4387680979 hasRelatedWork W2029910519 @default.
- W4387680979 hasRelatedWork W2292514593 @default.
- W4387680979 hasRelatedWork W2323977273 @default.
- W4387680979 hasRelatedWork W2418123811 @default.
- W4387680979 hasRelatedWork W3031573829 @default.
- W4387680979 hasRelatedWork W3080533456 @default.
- W4387680979 hasRelatedWork W3149918306 @default.
- W4387680979 hasRelatedWork W4310736182 @default.
- W4387680979 hasRelatedWork W90289501 @default.
- W4387680979 hasVolume "40" @default.
- W4387680979 isParatext "false" @default.
- W4387680979 isRetracted "false" @default.
- W4387680979 workType "article" @default.