Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387684467> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4387684467 endingPage "172" @default.
- W4387684467 startingPage "162" @default.
- W4387684467 abstract "Study Objectives . To characterize the effect of smoking cessation and nicotine replacement on pulmonary symptomatology, baseline pulmonary function and response to terbutaline, and purified T lymphocyte β 2 ‐receptor regulation; and the relationship between T lymphocyte β 2 ‐receptor density and pulmonary function. Design . Open‐label, longitudinal, 28‐week study. Setting . A university clinical research center. Patients . Eighteen long‐term smokers with mild to moderate chronic obstructive pulmonary disease (COPD) were enrolled and seven completed the study. Interventions . Subjects stopped smoking with the aid of nicotine substitution and behavioral counseling. Pulmonary response (FEVi) to subcutaneous terbutaline and T lymphocyte β 2 ‐receptor density (B max ) and function (cAMP) were measured prior to smoking cessation (week 0), during nicotine replacement (week 8), and after nicotine cessation (week 28). Measurements and Main Results . Serum cotinine concentrations, plasma epinephrine concentrations, and day and night cough decreased significantly after smoking cessation, whereas basal cAMP concentrations increased (p<0.05). No significant change was seen in baseline FEV 1 , pulmonary response to terbutaline, or B max over the 28 weeks; however, intrasubject changes in B max between visits correlated significantly (p<0.05) with intrasubject changes in pulmonary response between visits. Conclusions . Our data indicate that smoking cessation is associated with a significant decrease in the symptomatology of COPD, and that change in T lymphocyte β 2 ‐receptor density is a good marker of change in pulmonary response to β 2 ‐agonists." @default.
- W4387684467 created "2023-10-17" @default.
- W4387684467 creator A5012050942 @default.
- W4387684467 creator A5035265968 @default.
- W4387684467 creator A5073718044 @default.
- W4387684467 creator A5085271795 @default.
- W4387684467 date "1994-03-04" @default.
- W4387684467 modified "2023-10-17" @default.
- W4387684467 title "Symptomatology, Pulmonary Function and Response, and T Lymphocyte β2‐Receptors During Smoking Cessation in Patients With Chronic Obstructive Pulmonary Disease" @default.
- W4387684467 cites W1485474258 @default.
- W4387684467 cites W1551535764 @default.
- W4387684467 cites W1929197259 @default.
- W4387684467 cites W1938844474 @default.
- W4387684467 cites W1980480432 @default.
- W4387684467 cites W1982123427 @default.
- W4387684467 cites W1983882432 @default.
- W4387684467 cites W19938374 @default.
- W4387684467 cites W1997182468 @default.
- W4387684467 cites W2009077313 @default.
- W4387684467 cites W2021568033 @default.
- W4387684467 cites W2025409639 @default.
- W4387684467 cites W2026675160 @default.
- W4387684467 cites W2057135625 @default.
- W4387684467 cites W2059718063 @default.
- W4387684467 cites W2078186598 @default.
- W4387684467 cites W2083342276 @default.
- W4387684467 cites W2111774807 @default.
- W4387684467 cites W2124840772 @default.
- W4387684467 cites W2128010685 @default.
- W4387684467 cites W2156816514 @default.
- W4387684467 cites W2166780351 @default.
- W4387684467 cites W2327298537 @default.
- W4387684467 cites W2414869846 @default.
- W4387684467 cites W4211212338 @default.
- W4387684467 cites W4238017593 @default.
- W4387684467 doi "https://doi.org/10.1002/j.1875-9114.1994.tb02803.x" @default.
- W4387684467 hasPublicationYear "1994" @default.
- W4387684467 type Work @default.
- W4387684467 citedByCount "0" @default.
- W4387684467 crossrefType "journal-article" @default.
- W4387684467 hasAuthorship W4387684467A5012050942 @default.
- W4387684467 hasAuthorship W4387684467A5035265968 @default.
- W4387684467 hasAuthorship W4387684467A5073718044 @default.
- W4387684467 hasAuthorship W4387684467A5085271795 @default.
- W4387684467 hasConcept C126322002 @default.
- W4387684467 hasConcept C134018914 @default.
- W4387684467 hasConcept C142724271 @default.
- W4387684467 hasConcept C2776042228 @default.
- W4387684467 hasConcept C2776319443 @default.
- W4387684467 hasConcept C2776780178 @default.
- W4387684467 hasConcept C2777761686 @default.
- W4387684467 hasConcept C2777843972 @default.
- W4387684467 hasConcept C2779547902 @default.
- W4387684467 hasConcept C2780252434 @default.
- W4387684467 hasConcept C71924100 @default.
- W4387684467 hasConcept C75603125 @default.
- W4387684467 hasConceptScore W4387684467C126322002 @default.
- W4387684467 hasConceptScore W4387684467C134018914 @default.
- W4387684467 hasConceptScore W4387684467C142724271 @default.
- W4387684467 hasConceptScore W4387684467C2776042228 @default.
- W4387684467 hasConceptScore W4387684467C2776319443 @default.
- W4387684467 hasConceptScore W4387684467C2776780178 @default.
- W4387684467 hasConceptScore W4387684467C2777761686 @default.
- W4387684467 hasConceptScore W4387684467C2777843972 @default.
- W4387684467 hasConceptScore W4387684467C2779547902 @default.
- W4387684467 hasConceptScore W4387684467C2780252434 @default.
- W4387684467 hasConceptScore W4387684467C71924100 @default.
- W4387684467 hasConceptScore W4387684467C75603125 @default.
- W4387684467 hasIssue "2" @default.
- W4387684467 hasLocation W43876844671 @default.
- W4387684467 hasOpenAccess W4387684467 @default.
- W4387684467 hasPrimaryLocation W43876844671 @default.
- W4387684467 hasRelatedWork W114326178 @default.
- W4387684467 hasRelatedWork W1880389432 @default.
- W4387684467 hasRelatedWork W1963777072 @default.
- W4387684467 hasRelatedWork W2012474406 @default.
- W4387684467 hasRelatedWork W2012692477 @default.
- W4387684467 hasRelatedWork W2033163040 @default.
- W4387684467 hasRelatedWork W2162830511 @default.
- W4387684467 hasRelatedWork W2230094124 @default.
- W4387684467 hasRelatedWork W2519779702 @default.
- W4387684467 hasRelatedWork W2911888174 @default.
- W4387684467 hasVolume "14" @default.
- W4387684467 isParatext "false" @default.
- W4387684467 isRetracted "false" @default.
- W4387684467 workType "article" @default.