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- W438858 abstract "With regard to retroviral mediators of autoimmune/inflammatory diseases, coupled with genetic and environmental factors, it is clear that retroelements, in particular human endogenous retroviruses (HERVs), play a vital and significant role in the etiopathogenesis of such diseases. Because of the genetic diversity of exogenous and endogenous retroviruses, it has been difficult to delineate or identify specific retroviruses associated with specific autoimmune or inflammatory diseases. However, sequencing of the human genome and genome-wide scans of both humans and mice support the hypothesis of a HERV based etiopathogenesis for systemic lupus erythematosus (SLE). Specifically, it is proposed that molecular mimicry between the Gag-related region of (U1)snRNP and HRES-1 initiates the production of cross-reactive auto-antibodies and associated immune complexes. In addition to molecular mimicry, other mechanisms of autoimmunity brought about by HERVs include but are not limited to insertional mutagenesis, superantigen-type activity, cis- or trans-regulation of cellular genes, and immunomodulation by HERV gene products. Continued research in the field of autoimmune disease and HERVs as etiological factors will certainly facilitate the understanding of the very complex disease, SLE, as well as other autoimmune or inflammatory diseases." @default.
- W438858 created "2016-06-24" @default.
- W438858 creator A5025795347 @default.
- W438858 creator A5035668794 @default.
- W438858 creator A5051936450 @default.
- W438858 date "2004-01-01" @default.
- W438858 modified "2023-09-26" @default.
- W438858 title "Endogenous Retroviruses as Etiological Agents in Systemic Lupus Erythematosus" @default.
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