Matches in SemOpenAlex for { <https://semopenalex.org/work/W44017933> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W44017933 endingPage "401" @default.
- W44017933 startingPage "396" @default.
- W44017933 abstract "Peripheral blood natural killer (NK) activity in patients with B-cell chronic lymphocytic leukemia (B-CLL) is frequently low or absent. Because cimetidine (a histamine-2 antagonist) has been shown to alter human lymphocyte function in vitro, we decided to study cimetidine's effect on peripheral blood NK activity of patients with B-CLL and controls. We administered cimetidine orally (1.2 gm per day) to seven patients with B-CLL and 12 controls for up to 28 days. Peripheral blood NK activity of patients with B-CLL rose from a pretreatment level of 0.7 +/- 0.5 (mean +/- SEM) lytic units/10(6) cells (LU) to 8.7 +/- 2.4 LU (P less than 0.05) at day 28. Peripheral blood NK activity of controls decreased after 14 days of cimetidine treatment but returned to pretreatment levels by day 28. When peripheral blood cells from controls were exposed to cimetidine during in vitro incubation (10 micrograms/ml), mean NK activity was increased at 48 hours (54% +/- 22% increase over controls, n = 5, P less than 0.05). Single cell cytotoxicity assays revealed increased killing of target cells (but not effector-target conjugation) with cimetidine-exposed effector cells. These data suggest that cimetidine may be useful to augment peripheral blood NK activity for patients with B-CLL." @default.
- W44017933 created "2016-06-24" @default.
- W44017933 creator A5002515721 @default.
- W44017933 creator A5017998030 @default.
- W44017933 creator A5052849404 @default.
- W44017933 creator A5071887221 @default.
- W44017933 creator A5077484265 @default.
- W44017933 date "1987-04-01" @default.
- W44017933 modified "2023-09-27" @default.
- W44017933 title "Cimetidine modulates natural killer cell function of patients with chronic lymphocytic leukemia." @default.
- W44017933 cites W1480832200 @default.
- W44017933 cites W1605216847 @default.
- W44017933 cites W1849876075 @default.
- W44017933 cites W1912676133 @default.
- W44017933 cites W1938469722 @default.
- W44017933 cites W1975733065 @default.
- W44017933 cites W1999372457 @default.
- W44017933 cites W2005680325 @default.
- W44017933 cites W2043883666 @default.
- W44017933 cites W2045964137 @default.
- W44017933 cites W2073201889 @default.
- W44017933 cites W2091395732 @default.
- W44017933 cites W2093303627 @default.
- W44017933 cites W2094668768 @default.
- W44017933 cites W2100673560 @default.
- W44017933 cites W2122913682 @default.
- W44017933 cites W2144931720 @default.
- W44017933 cites W2145807988 @default.
- W44017933 cites W2161082695 @default.
- W44017933 cites W2272957544 @default.
- W44017933 cites W2292240319 @default.
- W44017933 cites W2337413481 @default.
- W44017933 cites W2418775240 @default.
- W44017933 cites W303730404 @default.
- W44017933 cites W89016691 @default.
- W44017933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3493314" @default.
- W44017933 hasPublicationYear "1987" @default.
- W44017933 type Work @default.
- W44017933 sameAs 44017933 @default.
- W44017933 citedByCount "12" @default.
- W44017933 crossrefType "journal-article" @default.
- W44017933 hasAuthorship W44017933A5002515721 @default.
- W44017933 hasAuthorship W44017933A5017998030 @default.
- W44017933 hasAuthorship W44017933A5052849404 @default.
- W44017933 hasAuthorship W44017933A5071887221 @default.
- W44017933 hasAuthorship W44017933A5077484265 @default.
- W44017933 hasConcept C109316439 @default.
- W44017933 hasConcept C1122143 @default.
- W44017933 hasConcept C126322002 @default.
- W44017933 hasConcept C134018914 @default.
- W44017933 hasConcept C202751555 @default.
- W44017933 hasConcept C203014093 @default.
- W44017933 hasConcept C2777761686 @default.
- W44017933 hasConcept C2777938653 @default.
- W44017933 hasConcept C2778102761 @default.
- W44017933 hasConcept C2778461978 @default.
- W44017933 hasConcept C2780719153 @default.
- W44017933 hasConcept C55493867 @default.
- W44017933 hasConcept C71924100 @default.
- W44017933 hasConcept C86803240 @default.
- W44017933 hasConcept C98274493 @default.
- W44017933 hasConceptScore W44017933C109316439 @default.
- W44017933 hasConceptScore W44017933C1122143 @default.
- W44017933 hasConceptScore W44017933C126322002 @default.
- W44017933 hasConceptScore W44017933C134018914 @default.
- W44017933 hasConceptScore W44017933C202751555 @default.
- W44017933 hasConceptScore W44017933C203014093 @default.
- W44017933 hasConceptScore W44017933C2777761686 @default.
- W44017933 hasConceptScore W44017933C2777938653 @default.
- W44017933 hasConceptScore W44017933C2778102761 @default.
- W44017933 hasConceptScore W44017933C2778461978 @default.
- W44017933 hasConceptScore W44017933C2780719153 @default.
- W44017933 hasConceptScore W44017933C55493867 @default.
- W44017933 hasConceptScore W44017933C71924100 @default.
- W44017933 hasConceptScore W44017933C86803240 @default.
- W44017933 hasConceptScore W44017933C98274493 @default.
- W44017933 hasIssue "4" @default.
- W44017933 hasLocation W440179331 @default.
- W44017933 hasOpenAccess W44017933 @default.
- W44017933 hasPrimaryLocation W440179331 @default.
- W44017933 hasRelatedWork W1965692775 @default.
- W44017933 hasRelatedWork W1983315707 @default.
- W44017933 hasRelatedWork W1985331523 @default.
- W44017933 hasRelatedWork W1999211995 @default.
- W44017933 hasRelatedWork W2005432427 @default.
- W44017933 hasRelatedWork W2010120662 @default.
- W44017933 hasRelatedWork W2072399816 @default.
- W44017933 hasRelatedWork W2076906435 @default.
- W44017933 hasRelatedWork W2094747554 @default.
- W44017933 hasRelatedWork W2172131010 @default.
- W44017933 hasVolume "109" @default.
- W44017933 isParatext "false" @default.
- W44017933 isRetracted "false" @default.
- W44017933 magId "44017933" @default.
- W44017933 workType "article" @default.