Matches in SemOpenAlex for { <https://semopenalex.org/work/W44162751> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W44162751 endingPage "260" @default.
- W44162751 startingPage "257" @default.
- W44162751 abstract "A seventy-seven year-old woman with an unclear tumor of the liver suffered from recurrent hypoglycemia and was therefore admitted to our hospital. As diabetes mellitus, hyperinsulinism and reactive forms of hypoglycemia could be excluded, the presumptive diagnosis was non-islet-cell tumor hypoglycemia (NICTH).Postprandial glucose levels were normal. Fasting glucose levels were 30 - 50 mg/dl. Plasma insulin-like growth factor (IGF)-I was below the normal range, IGF-II was not elevated, although 34 % of plasma IGF-II was present as big-IGF-II. IGF-binding protein (IGFBP)-2 was extremely elevated, whereas IGFBP-3 was within the normal range. Histological examinations of the tumor revealed a hemangiopericytoma of the liver.: After a 2-month treatment with steroids and an experimental antiangiogenetic therapy, the glucose metabolism became stable. The tumour did not grow. Simultaneously, plasma IGF-II and big-IGF-II remained constant and plasma IGF-I level improved slightly. IGFBP-2, which is presumable produced by the tumor, increased, IGFBP-3 fell below the normal range.NICTH is a rare but important differential diagnosis of recurrent hypoglycemia. The tumor derived IGF-II has a higher than normal molecular weight (big-IGF-II) and shows different interactions with binding proteins, thus resulting in an increased bioavailability. An increased glucose uptake in different tissues as well as inhibition of hepatic gluconeogenesis and lipolysis lead to severe hypoglycemia. If surgical therapy of the tumor is not possible, symptomatic treatment with steroids may represent an effective alternative to control severe hypoglycemia." @default.
- W44162751 created "2016-06-24" @default.
- W44162751 creator A5012851124 @default.
- W44162751 creator A5020818471 @default.
- W44162751 creator A5041945240 @default.
- W44162751 creator A5085030460 @default.
- W44162751 date "2003-02-06" @default.
- W44162751 modified "2023-09-24" @default.
- W44162751 title "Hypoglykämien bei malignem Hämangioperizytom der Leber" @default.
- W44162751 doi "https://doi.org/10.1055/s-2003-37075" @default.
- W44162751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12571793" @default.
- W44162751 hasPublicationYear "2003" @default.
- W44162751 type Work @default.
- W44162751 sameAs 44162751 @default.
- W44162751 citedByCount "7" @default.
- W44162751 countsByYear W441627512013 @default.
- W44162751 countsByYear W441627512016 @default.
- W44162751 countsByYear W441627512019 @default.
- W44162751 crossrefType "journal-article" @default.
- W44162751 hasAuthorship W44162751A5012851124 @default.
- W44162751 hasAuthorship W44162751A5020818471 @default.
- W44162751 hasAuthorship W44162751A5041945240 @default.
- W44162751 hasAuthorship W44162751A5085030460 @default.
- W44162751 hasConcept C126322002 @default.
- W44162751 hasConcept C134018914 @default.
- W44162751 hasConcept C2776297358 @default.
- W44162751 hasConcept C2777368190 @default.
- W44162751 hasConcept C2777391703 @default.
- W44162751 hasConcept C2778199505 @default.
- W44162751 hasConcept C2779306644 @default.
- W44162751 hasConcept C2780668416 @default.
- W44162751 hasConcept C2780988686 @default.
- W44162751 hasConcept C555293320 @default.
- W44162751 hasConcept C71924100 @default.
- W44162751 hasConceptScore W44162751C126322002 @default.
- W44162751 hasConceptScore W44162751C134018914 @default.
- W44162751 hasConceptScore W44162751C2776297358 @default.
- W44162751 hasConceptScore W44162751C2777368190 @default.
- W44162751 hasConceptScore W44162751C2777391703 @default.
- W44162751 hasConceptScore W44162751C2778199505 @default.
- W44162751 hasConceptScore W44162751C2779306644 @default.
- W44162751 hasConceptScore W44162751C2780668416 @default.
- W44162751 hasConceptScore W44162751C2780988686 @default.
- W44162751 hasConceptScore W44162751C555293320 @default.
- W44162751 hasConceptScore W44162751C71924100 @default.
- W44162751 hasIssue "06" @default.
- W44162751 hasLocation W441627511 @default.
- W44162751 hasLocation W441627512 @default.
- W44162751 hasOpenAccess W44162751 @default.
- W44162751 hasPrimaryLocation W441627511 @default.
- W44162751 hasRelatedWork W1948194447 @default.
- W44162751 hasRelatedWork W2046155875 @default.
- W44162751 hasRelatedWork W2053519879 @default.
- W44162751 hasRelatedWork W2057434408 @default.
- W44162751 hasRelatedWork W2083753940 @default.
- W44162751 hasRelatedWork W2088717006 @default.
- W44162751 hasRelatedWork W2089620300 @default.
- W44162751 hasRelatedWork W2097857221 @default.
- W44162751 hasRelatedWork W2129737421 @default.
- W44162751 hasRelatedWork W2441371598 @default.
- W44162751 hasVolume "128" @default.
- W44162751 isParatext "false" @default.
- W44162751 isRetracted "false" @default.
- W44162751 magId "44162751" @default.
- W44162751 workType "article" @default.