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- W44163912 abstract "This chapter presents the studies on liver and kidney drug, and lauric acid monooxygenases in microsomal and reconstituted systems. The liver microsomal monooxygenase system metabolizes a broad spectrum of substrates, including xenobiotics, steroids, and fatty acids. However, the kidney microsomal monooxygenase system, while containing the same components as the liver system, metabolizes fatty acids at a higher specific activity than any other known substrate. The chapter describes a comparative study of the reductases and cytochromes P-450 of pig liver and kidney microsomes that was carried out to elucidate the differences in substrate specificity between the two organs. In this study, the purified kidney cytochrome P-450 from untreated pigs was found to be immunochemically distinct from the purified liver cytochrome P-450 from phenobarbital (PB)–induced pigs. In addition, differences between these purified cytochromes P-450 were found in benzphetamine demethylation and laurate hydroxylation activities measured in reconstituted systems. The two cytochromes P-450 that were isolated from liver microsomes of PB-induced pigs and from kidney microsomes of untreated pigs show no immunochemical cross-reactivity. They exhibit distinct substrate specificities that are affected neither by lipid milieu nor by the source of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH)–cytochrome P-450 reductase." @default.
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- W44163912 date "1980-01-01" @default.
- W44163912 modified "2023-09-27" @default.
- W44163912 title "STUDIES ON LIVER AND KIDNEY DRUG AND LAURIC ACID MONOOXYGENASES IN BOTH MICROSOMAL AND RECONSTITUTED SYSTEMS." @default.
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- W44163912 doi "https://doi.org/10.1016/b978-0-12-187702-6.50031-1" @default.
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