Matches in SemOpenAlex for { <https://semopenalex.org/work/W44181750> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W44181750 endingPage "174" @default.
- W44181750 startingPage "169" @default.
- W44181750 abstract "Objectives: The aim of this study was to investigate the effect of A. booneistem bark extracts on immune system in vitro using complement system and polymorphonuclear (PMN) leucocytes as immunological parameters.Methods: Pulverized stem bark of A. boonei was defatted with petroleum ether and extracted with diethylether (DE), ethylacetate (EA), ethanol (EtOH) and water (AQ). Their anticomplementary activity was investigated on classical (CP) and alternative (AP) pathways of complement-mediated haemolysis using human serum and antibody-sensitized sheep erythrocytes (CP) or rabbit erythrocytes (AP). Their effects on phagocytic activity of PMN was assessed by using PMNs isolated from venous blood of healthy volunteers, serum treated zymosan, and luminol solution. Chemiluinescence was induced by zymosan.Results: DE and EA extracts showed strong inhibition in the CP-mediated haemolysis whereas EtOH and AQ extracts showed little inhibition. None of the extracts inhibited AP-mediated haemolysis. The anticomplementary action of the active extracts increased with increase in temperature and time of preincubation. None of the extracts inhibited the chemiluminescence generated by stimulated PMNs.Conclusion: Some extracts of A. boonei stem bark (ABSB) have in vitro anticomplementary activity which is mediated through the classical pathway.The anticomplementary action may be the reason for its beneficial effect in rheumatoid arthritis." @default.
- W44181750 created "2016-06-24" @default.
- W44181750 creator A5007302353 @default.
- W44181750 creator A5007344044 @default.
- W44181750 creator A5043960350 @default.
- W44181750 creator A5053316575 @default.
- W44181750 creator A5084446746 @default.
- W44181750 creator A5090855225 @default.
- W44181750 date "1998-05-01" @default.
- W44181750 modified "2023-09-27" @default.
- W44181750 title "Activity of the stem bark extract of Alstonia Boonei de Wild (Apocynaceae) on human complement and polymorphonuclear leukocytes" @default.
- W44181750 hasPublicationYear "1998" @default.
- W44181750 type Work @default.
- W44181750 sameAs 44181750 @default.
- W44181750 citedByCount "6" @default.
- W44181750 countsByYear W441817502013 @default.
- W44181750 countsByYear W441817502014 @default.
- W44181750 countsByYear W441817502016 @default.
- W44181750 crossrefType "journal-article" @default.
- W44181750 hasAuthorship W44181750A5007302353 @default.
- W44181750 hasAuthorship W44181750A5007344044 @default.
- W44181750 hasAuthorship W44181750A5043960350 @default.
- W44181750 hasAuthorship W44181750A5053316575 @default.
- W44181750 hasAuthorship W44181750A5084446746 @default.
- W44181750 hasAuthorship W44181750A5090855225 @default.
- W44181750 hasConcept C111684460 @default.
- W44181750 hasConcept C185592680 @default.
- W44181750 hasConcept C202751555 @default.
- W44181750 hasConcept C203014093 @default.
- W44181750 hasConcept C2778870864 @default.
- W44181750 hasConcept C2779902561 @default.
- W44181750 hasConcept C2780007248 @default.
- W44181750 hasConcept C2910801743 @default.
- W44181750 hasConcept C55493867 @default.
- W44181750 hasConcept C556039675 @default.
- W44181750 hasConcept C71924100 @default.
- W44181750 hasConcept C86803240 @default.
- W44181750 hasConcept C8891405 @default.
- W44181750 hasConcept C98274493 @default.
- W44181750 hasConceptScore W44181750C111684460 @default.
- W44181750 hasConceptScore W44181750C185592680 @default.
- W44181750 hasConceptScore W44181750C202751555 @default.
- W44181750 hasConceptScore W44181750C203014093 @default.
- W44181750 hasConceptScore W44181750C2778870864 @default.
- W44181750 hasConceptScore W44181750C2779902561 @default.
- W44181750 hasConceptScore W44181750C2780007248 @default.
- W44181750 hasConceptScore W44181750C2910801743 @default.
- W44181750 hasConceptScore W44181750C55493867 @default.
- W44181750 hasConceptScore W44181750C556039675 @default.
- W44181750 hasConceptScore W44181750C71924100 @default.
- W44181750 hasConceptScore W44181750C86803240 @default.
- W44181750 hasConceptScore W44181750C8891405 @default.
- W44181750 hasConceptScore W44181750C98274493 @default.
- W44181750 hasIssue "3" @default.
- W44181750 hasLocation W441817501 @default.
- W44181750 hasOpenAccess W44181750 @default.
- W44181750 hasPrimaryLocation W441817501 @default.
- W44181750 hasRelatedWork W1972138696 @default.
- W44181750 hasRelatedWork W1976131457 @default.
- W44181750 hasRelatedWork W1990023475 @default.
- W44181750 hasRelatedWork W1992405382 @default.
- W44181750 hasRelatedWork W1995825132 @default.
- W44181750 hasRelatedWork W2080592840 @default.
- W44181750 hasRelatedWork W2089629885 @default.
- W44181750 hasRelatedWork W2089811342 @default.
- W44181750 hasRelatedWork W2408506684 @default.
- W44181750 hasRelatedWork W2497685525 @default.
- W44181750 hasRelatedWork W2782877178 @default.
- W44181750 hasRelatedWork W2889326457 @default.
- W44181750 hasRelatedWork W2983502266 @default.
- W44181750 hasRelatedWork W2983586034 @default.
- W44181750 hasRelatedWork W2994408938 @default.
- W44181750 hasRelatedWork W3041249680 @default.
- W44181750 hasRelatedWork W3135079352 @default.
- W44181750 hasRelatedWork W2398421323 @default.
- W44181750 hasRelatedWork W2520679195 @default.
- W44181750 hasRelatedWork W2740481965 @default.
- W44181750 hasVolume "30" @default.
- W44181750 isParatext "false" @default.
- W44181750 isRetracted "false" @default.
- W44181750 magId "44181750" @default.
- W44181750 workType "article" @default.