FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W44202489> ?p ?o ?g. }

• W44202489 endingPage "638" @default.
• W44202489 startingPage "633" @default.
• W44202489 abstract "Adjusted-dose warfarin is highly efficacious for prevention of ischaemic stroke in patients with atrial fibrillation (AF). However, this treatment carries a risk of bleeding and the need for frequent medical monitoring. We sought an alternative that would be safer and easier to administer to patients with AF who are at high-risk of thromboembolism.1044 patients with AF and with at least one thromboembolic risk factor (congestive heart failure or left ventricular fractional shortening < or = 25%, previous thromboembolism, systolic blood pressure of more than 160 mm Hg at study enrollment, or being a woman aged over 75 years) were randomly assigned either a combination of low-intensity, fixed-dose warfarin (international normalised ratio [INR] 1.2-1.5 for initial dose adjustment) and aspirin (325 mg/day) or adjusted-dose warfarin (INR 2.0-3.0). Drugs were given open-labelled.The mean INR during follow-up of patients taking combination therapy (n = 521) was 1.3, compared with 2.4 for those taking adjusted-dose warfarin (n = 523). During follow-up, 54% of INRs in patients taking combination therapy were 1.2-1.5 and 34% were less than 1.2. The trial was stopped after a mean, follow-up of 1.1 years when the rate of ischaemic stroke and systemic embolism (primary events) in patients given combination therapy (7.9% per year) was significantly higher than in those given adjusted-dose warfarin (1.9% per year) at an interim analysis (p < 0.0001), an absolute reduction of 6.0% per year (95% Cl 3.4, 8.6) by adjusted-dose warfarin. The annual rates of disabling stroke (5.6% vs 1.7%, p = 0.0007) and of primary event or vascular death (11.8% vs 6.4%, p = 0.002), were also higher with combination therapy. The rates of major bleeding were similar in both treatment groups.Low-intensity, fixed-dose warfarin plus aspirin in this regimen is insufficient for stroke prevention in patients with non-valvular AF at high-risk for thromboembolism; adjusted-dose warfarin (target INR 2.0-3.0) importantly reduces stroke for high-risk patients." @default.
• W44202489 created "2016-06-24" @default.
• W44202489 creator A5000707058 @default.
• W44202489 creator A5001880517 @default.
• W44202489 creator A5002041395 @default.
• W44202489 creator A5002069627 @default.
• W44202489 creator A5002862479 @default.
• W44202489 creator A5002912592 @default.
• W44202489 creator A5003231882 @default.
• W44202489 creator A5006256796 @default.
• W44202489 creator A5006633268 @default.
• W44202489 creator A5007573855 @default.
• W44202489 creator A5008096256 @default.
• W44202489 creator A5008371852 @default.
• W44202489 creator A5010209795 @default.
• W44202489 creator A5010308589 @default.
• W44202489 creator A5011253738 @default.
• W44202489 creator A5011404194 @default.
• W44202489 creator A5011945038 @default.
• W44202489 creator A5011989714 @default.
• W44202489 creator A5012335071 @default.
• W44202489 creator A5012699238 @default.
• W44202489 creator A5013189391 @default.
• W44202489 creator A5013436232 @default.
• W44202489 creator A5013825877 @default.
• W44202489 creator A5014334074 @default.
• W44202489 creator A5016571028 @default.
• W44202489 creator A5018928871 @default.
• W44202489 creator A5019106472 @default.
• W44202489 creator A5019547551 @default.
• W44202489 creator A5019633786 @default.
• W44202489 creator A5020758053 @default.
• W44202489 creator A5021803851 @default.
• W44202489 creator A5022121883 @default.
• W44202489 creator A5024877375 @default.
• W44202489 creator A5027056643 @default.
• W44202489 creator A5027955212 @default.
• W44202489 creator A5028179172 @default.
• W44202489 creator A5029033862 @default.
• W44202489 creator A5029484077 @default.
• W44202489 creator A5029519359 @default.
• W44202489 creator A5029673005 @default.
• W44202489 creator A5029796358 @default.
• W44202489 creator A5029901097 @default.
• W44202489 creator A5030159733 @default.
• W44202489 creator A5030354362 @default.
• W44202489 creator A5031002239 @default.
• W44202489 creator A5031038693 @default.
• W44202489 creator A5031955558 @default.
• W44202489 creator A5032400867 @default.
• W44202489 creator A5032597849 @default.
• W44202489 creator A5032666674 @default.
• W44202489 creator A5032669172 @default.
• W44202489 creator A5033555215 @default.
• W44202489 creator A5033948796 @default.
• W44202489 creator A5034102442 @default.
• W44202489 creator A5034280171 @default.
• W44202489 creator A5034588600 @default.
• W44202489 creator A5035009607 @default.
• W44202489 creator A5035106740 @default.
• W44202489 creator A5036136568 @default.
• W44202489 creator A5037609927 @default.
• W44202489 creator A5038321413 @default.
• W44202489 creator A5039978768 @default.
• W44202489 creator A5040287906 @default.
• W44202489 creator A5040485133 @default.
• W44202489 creator A5040885668 @default.
• W44202489 creator A5041263520 @default.
• W44202489 creator A5042780321 @default.
• W44202489 creator A5043735934 @default.
• W44202489 creator A5044851820 @default.
• W44202489 creator A5046138159 @default.
• W44202489 creator A5047969297 @default.
• W44202489 creator A5049152371 @default.
• W44202489 creator A5049423334 @default.
• W44202489 creator A5049511125 @default.
• W44202489 creator A5049702998 @default.
• W44202489 creator A5049841379 @default.
• W44202489 creator A5050144897 @default.
• W44202489 creator A5050737232 @default.
• W44202489 creator A5050756533 @default.
• W44202489 creator A5050999614 @default.
• W44202489 creator A5052630969 @default.
• W44202489 creator A5052654568 @default.
• W44202489 creator A5053088701 @default.
• W44202489 creator A5053815857 @default.
• W44202489 creator A5054365760 @default.
• W44202489 creator A5055168814 @default.
• W44202489 creator A5055472357 @default.
• W44202489 creator A5055498673 @default.
• W44202489 creator A5056029675 @default.
• W44202489 creator A5056828619 @default.
• W44202489 creator A5057169790 @default.
• W44202489 creator A5057301267 @default.
• W44202489 creator A5057333842 @default.
• W44202489 creator A5057871176 @default.
• W44202489 creator A5059795697 @default.
• W44202489 creator A5059854579 @default.

• next