Matches in SemOpenAlex for { <https://semopenalex.org/work/W44238429> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W44238429 abstract "Syndecans are a family of heparan sulfate proteoglycans that regulate the interaction between cell-surface receptors and extracellular ligands. We found that syndecan-4 expression is strongly induced in spleen after infection with Listeria monocytogenes and in macrophages stimulated with Toll-like receptor (TLR) agonists. To examine the function of syndecan-4 in immunity, wild-type and syndecan-4 knockout mice were infected with L. monocytogenes and their ability to resist the infection was determined. Syndecan-4 knockout mice exhibited greatly increased bacterial burdens in spleen and liver, indicating that syndecan-4 plays an important role in fighting listerial infection. Macrophages that recognized infected microbes produce a battery of proinflammatory cytokines and thereby alert other immune cells to the presence of an infectious agent. Syndecan-4-deficient macrophages were defective in inducing the transcription of the interleukin (IL)-12 subunit p40 in response to TLR agonists, suggesting that syndecan-4 is required for linking TLR signaling to IL-12 p40 transcription and promote the immune response to L. monocytogenes. This study was supported by a grant to the Cutaneous Biology Research Center from Shiseido, Ltd." @default.
- W44238429 created "2016-06-24" @default.
- W44238429 creator A5037534545 @default.
- W44238429 creator A5045970179 @default.
- W44238429 creator A5054940911 @default.
- W44238429 creator A5056028875 @default.
- W44238429 creator A5061336193 @default.
- W44238429 creator A5065610431 @default.
- W44238429 creator A5089442069 @default.
- W44238429 date "2006-03-01" @default.
- W44238429 modified "2023-09-23" @default.
- W44238429 title "Syndecan‐4 is required for Toll‐like receptor‐dependent interleukin‐12 production and host resistance to microbial infection" @default.
- W44238429 doi "https://doi.org/10.1096/fasebj.20.5.lb58-b" @default.
- W44238429 hasPublicationYear "2006" @default.
- W44238429 type Work @default.
- W44238429 sameAs 44238429 @default.
- W44238429 citedByCount "0" @default.
- W44238429 crossrefType "journal-article" @default.
- W44238429 hasAuthorship W44238429A5037534545 @default.
- W44238429 hasAuthorship W44238429A5045970179 @default.
- W44238429 hasAuthorship W44238429A5054940911 @default.
- W44238429 hasAuthorship W44238429A5056028875 @default.
- W44238429 hasAuthorship W44238429A5061336193 @default.
- W44238429 hasAuthorship W44238429A5065610431 @default.
- W44238429 hasAuthorship W44238429A5089442069 @default.
- W44238429 hasConcept C136449434 @default.
- W44238429 hasConcept C1491633281 @default.
- W44238429 hasConcept C164027704 @default.
- W44238429 hasConcept C170493617 @default.
- W44238429 hasConcept C203014093 @default.
- W44238429 hasConcept C2776709828 @default.
- W44238429 hasConcept C2776914184 @default.
- W44238429 hasConcept C2780931953 @default.
- W44238429 hasConcept C2781350384 @default.
- W44238429 hasConcept C523546767 @default.
- W44238429 hasConcept C54355233 @default.
- W44238429 hasConcept C55493867 @default.
- W44238429 hasConcept C65001120 @default.
- W44238429 hasConcept C86803240 @default.
- W44238429 hasConcept C8891405 @default.
- W44238429 hasConcept C89423630 @default.
- W44238429 hasConcept C95444343 @default.
- W44238429 hasConceptScore W44238429C136449434 @default.
- W44238429 hasConceptScore W44238429C1491633281 @default.
- W44238429 hasConceptScore W44238429C164027704 @default.
- W44238429 hasConceptScore W44238429C170493617 @default.
- W44238429 hasConceptScore W44238429C203014093 @default.
- W44238429 hasConceptScore W44238429C2776709828 @default.
- W44238429 hasConceptScore W44238429C2776914184 @default.
- W44238429 hasConceptScore W44238429C2780931953 @default.
- W44238429 hasConceptScore W44238429C2781350384 @default.
- W44238429 hasConceptScore W44238429C523546767 @default.
- W44238429 hasConceptScore W44238429C54355233 @default.
- W44238429 hasConceptScore W44238429C55493867 @default.
- W44238429 hasConceptScore W44238429C65001120 @default.
- W44238429 hasConceptScore W44238429C86803240 @default.
- W44238429 hasConceptScore W44238429C8891405 @default.
- W44238429 hasConceptScore W44238429C89423630 @default.
- W44238429 hasConceptScore W44238429C95444343 @default.
- W44238429 hasIssue "5" @default.
- W44238429 hasLocation W442384291 @default.
- W44238429 hasOpenAccess W44238429 @default.
- W44238429 hasPrimaryLocation W442384291 @default.
- W44238429 hasRelatedWork W1925605163 @default.
- W44238429 hasRelatedWork W2019596936 @default.
- W44238429 hasRelatedWork W2036107469 @default.
- W44238429 hasRelatedWork W2048363111 @default.
- W44238429 hasRelatedWork W2081358646 @default.
- W44238429 hasRelatedWork W2103515427 @default.
- W44238429 hasRelatedWork W2156589187 @default.
- W44238429 hasRelatedWork W2413634434 @default.
- W44238429 hasRelatedWork W2898568897 @default.
- W44238429 hasRelatedWork W2781693618 @default.
- W44238429 hasVolume "20" @default.
- W44238429 isParatext "false" @default.
- W44238429 isRetracted "false" @default.
- W44238429 magId "44238429" @default.
- W44238429 workType "article" @default.