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- W44256802 abstract "The last few years have seen an explosion in the publication of gene association studies, particularly genome wide analyses, giving insight into the molecular underpinnings of disease [1, 2]. For acute lung injury (ALI), the field of genetics is just beginning to move past its infancy, from candidate gene studies to higher throughput, hypothesis-generating designs. As a phenotype, ALI can be challenging to study given the lack of available pedigrees for family-based analyses, the necessity for a severe environmental insult such as sepsis, pneumonia, trauma, or aspiration, and the heterogeneity of the populations at-risk for the syndrome and those who manifest it [3]. The search to identify genetic risk factors for ALI susceptibility or outcome draws input from molecular advances as well as from large epidemiological studies with carefully phenotyped critically ill subjects, and these efforts in tandem have recently produced exciting results. In this chapter, we will discuss the most recent developments in the effort to identify genetic risk factors contributing to ALI susceptibility or outcome, and will highlight the more novel techniques applied to this question. A glossary of genetic terms is provided (Box)." @default.
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- W44256802 date "2011-01-01" @default.
- W44256802 modified "2023-09-26" @default.
- W44256802 title "The Next Generation of ALI Genetics: Insights into Pathophysiology" @default.
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- W44256802 doi "https://doi.org/10.1007/978-3-642-18081-1_9" @default.
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