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- W44397443 abstract "The nuclear receptor Liver Receptor Homolog-1 (LRH-1) plays a key role in several biological processes. The correlative association between LRH-1 function induced by estrogens and the protective role of the hormone on pancreatic insulin-secreting s-cells led us to investigate the potential implication of LRH-1 in islet s-cell physiology. We demonstrate that LRH-1 is expressed in s-cells and that transcript levels are modulated by 17s-estradiol through the ERa signalling pathway. Adenoviral-mediated overexpression of LRH-1 in human islets did not alter proliferation but conferred protection against cytokines and streptozotocin-induced apoptosis. More importantly, incubation of human islets with an agonist of LRH-1 (BL001) also protected islets against cell death caused by cytokines and streptozotocin. BL001 also increased overall s-cell performance in islets isolated from Type 2 diabetic donors. Our results indicate that LRH-1 could be an attractive target for stimulating islet survival and performance in diabetic patients." @default.
- W44397443 created "2016-06-24" @default.
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- W44397443 date "2010-01-01" @default.
- W44397443 modified "2023-09-26" @default.
- W44397443 title "Role of LRH-1/NR5A2 in islet physiology and pathophysiology" @default.
- W44397443 hasPublicationYear "2010" @default.
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