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- W44407524 abstract "to assess the variability of the levels of chromosome aberrations induced by the in vitro irradiation of lymphocytes of breast cancer (BC) patients in comparison with healthy individuals. Materials and methods. Samples of peripheral blood for lymphocyte cultures were obtained from 44 healthy women and 37 primary patients with BC (T1-2N1M0). Lymphocyte X-ray irradiation was carried out at G0 and G2 phase of lymphocyte cell cycle (G0 and G2 assay) with the dose of 1,5 Gy before PHA stimulation in G0 assay and 0,5 Gy - at 47 h of cultivation in G2 assay. Preparations of metaphase chromosomes were made according standard protocols. Results and conclusions. Inter-individual variation of G2 chromosome aberration yields was significantly higher in comparison with G0 chromosomal radiosensitivity in both examined groups. According to G2 assay the fraction of individuals with elevated chromosomal radiosensitivity among healthy women and BC patients was 11.4 and 38 %, respectively. The results obtained support the concept of association between predisposition to BC, radiationinduced G2 chromosomal instability and efficiency of DNA repair activated by cell irradiation in G2 phase. It is assumed that individuals with elevated G2 aberration scores from the control group need further examinations on the BC risk and primary prevention of radiation induced cancer.Meta roboty: ocinyty variabel'nist' chastoty aberacij hromosom, indukovanyh in vitro oprominennjam v limfocytah peryferychnoi' krovi (LPK) hvoryh na rak grudnoi' zalozy (RGZ) v riznyh fazah klitynnogo cyklu u porivnjanni z umovno zdorovymy osobamy. Materialy i metody. Zrazky peryferychnoi' krovi dlja postanovky kul'tur LPK otrymano u 44 umovno zdorovyh zhinok ta u 37 zhinok, pervynnyh hvoryh na RGZ I–II stadii' (T1–2N1M0). Oprominennja klityn zdijsnjuvaly v G0 ta G2 fazi klitynnogo cyklu (G0 ta G2-test) rentgenivs'kymy promenjamy v dozi 1,5 Gr pered stymuljacijeju limfocytiv FGA (G0 test) ta v dozi 0,5 Gr na 47 god kul'tyvuvannja (G2 test). Prygotuvannja preparativ metafaznyh hromosom zdijsnjuvaly za standartnoju metodykoju. Rezul'taty i vysnovky. Mizhindyvidual'na variabel'nist' rivniv aberacij hromosom, indukovanyh oprominennjam v G2 fazi, bula znachno vyshhoju u porivnjanni z G0 oprominennjam jak u grupi zdorovyh donoriv, tak i hvoryh na RGZ. Za danymy G2 testu chastka osib z pidvyshhenoju radiacijnoju chutlyvistju LPK sklala 11,4 % sered zdorovyh donoriv ta 38 % sered hvoryh na RGZ. Oderzhani rezul'taty svidchat' na koryst' gipotezy pro zv'jazok RGZ, hromosomnoi' nestabil'nosti, shho vyjavljajet'sja pry oprominenni LPK v G2-fazi, ta efektyvnistju procesiv reparacii' radiacijno-indukovanyh poshkodzhen' DNK v cij fazi klitynnogo cyklu. Osoby z grupy zdorovogo kontrolju z pidvyshhenoju radiacijnoju chutlyvistju LPK, vyznachenoju za G2 testom, vymagajut' podal'shyh obstezhen' z metoju vstanovlennja shyl'nosti do RGZ ta pervynnoi' profilaktyky radiacijno-indukovanyh zlojakisnyh patologij." @default.
- W44407524 created "2016-06-24" @default.
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- W44407524 date "2014-09-01" @default.
- W44407524 modified "2023-09-23" @default.
- W44407524 title "Radiation-induced chromosomal instability of human lymphocytes as a marker of breast cancer risk." @default.
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