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• W444946657 abstract "ABSTRACT The analysis of the transcription pattern of a 36 kb genomic region surrounding the human interferon s gene lead to the identification of some five “genes” which are inducible with poly(rI):(rC) in h u man fibroblasts. Transfer of this DNA into mouse Ltk -cells leads to transient expression of human interferon, independently of the presence of normal inducer. Constitutive interferon expression was found in most stable clones, which is further inducible to a high level (NDV) in a manner characteristic for mouse cells. The induced transcript is identical to normal human IFNs mRNA. Neighbouring genes are not essential for the human interferon production in mouse L cells since inducible clones can still be obtained by transformation with a 1.8 kb EcoRI fragment which contains only 280 bp 5′-distal to the IFN-s gene transcription start. The mouse cell clones may provide a feasible alternative source of human IFNs for large-scale production since the hu IFNs appears, from its molecular weight, to be glucosylated to the same extent as it is in human fibroblasts." @default.
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• W444946657 date "1982-01-01" @default.
• W444946657 modified "2023-09-25" @default.
• W444946657 title "REGULATION OF THE HUMAN INTERFERON ß GENE IN MOUSE L CELL CLONES AND IN HUMAN CELLS" @default.
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• W444946657 doi "https://doi.org/10.1016/b978-0-12-491220-5.50009-4" @default.
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