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- W4454839 abstract "A study was carried out to find out the therapeutic implications of the tolbutamide - ketoconazole interaction in diabetic rabbits. Ketoconazole treatment (20 mgkg, oral once daily for one week) significantly increased and prolonged the antidiabetic effect of tolbutamide (40 mg/kg, oral) in diabetic rabbits. The AUC0-( and the terminal half-life of tolbutamide were increased significantly by ketoconazole indicating the decrease in its hepatic metabolism." @default.
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- W4454839 date "1993-07-01" @default.
- W4454839 modified "2023-09-26" @default.
- W4454839 title "Drug interaction of tolbutamide with ketoconazole in diabetic rabbits" @default.
- W4454839 hasPublicationYear "1993" @default.
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