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- W44549084 abstract "Adipocyte differentiation plays an important role in many human diseases, including obesity, diabetes mellitus and hypertension. Pak2 has been studied to arrest cell cycle progression, phosphorylate c-Myc and regulate stem cell differentiation. To study whether Pak2 regulates 3T3-L1 cell differentiation, the changes in Pak2 were first analyzed during adipogenesis. It was found that the amounts of Pak2 were increased by 2-3 folds as compared to the control from the day 2 to day 6 of induction, and then declined down to the levels of control. The level of Pak1 was constant during the same period of time. This result suggested that Pak2 could regulate 3T3-L1 cell differentiation. With 3T3-L1 cell lines stably transfected with Pak2, it was shown that over-expression of WT-Pak2 enhanced the progression of differentiation. The numbers of differentiated cells at day 4 were largely increased, but the final differentiated adipocytes were less than the control. In contrast, the kinase-inactive mutant of Pak2 (K278R) completely abolished the differentiation in 3T3-L1 cells, hence identifying that Pak2 is a key regulator of initiation of differentiation in the preadipocyte. Further analysis detected that WT Pak2 activated c-Myc and PPARγ, but K/R did not support the elevated level of PPARγ at the intermediate stage, which accounted for one of mechanisms that Pak2 regulated 3T3-L1 cell differentiation." @default.
- W44549084 created "2016-06-24" @default.
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- W44549084 date "2009-04-01" @default.
- W44549084 modified "2023-10-17" @default.
- W44549084 title "Small G‐protein Activated Kinase Pak2 Promotes 3T3‐L1 Preadipocyte Differentiation" @default.
- W44549084 doi "https://doi.org/10.1096/fasebj.23.1_supplement.lb291" @default.
- W44549084 hasPublicationYear "2009" @default.
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